Fmoc-L-glutamic acid α-9-fluorenylmethyl ester
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Fmoc-L-glutamic acid α-9-fluorenylmethyl ester

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Category
Fmoc-Amino Acids
Catalog number
BAT-003751
CAS number
200616-18-8
Molecular Formula
C34H29NO6
Molecular Weight
547.61
Fmoc-L-glutamic acid α-9-fluorenylmethyl ester
IUPAC Name
(4S)-5-(9H-fluoren-9-ylmethoxy)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid
Synonyms
Fmoc-L-Glu-OFm; Fmoc-L-glutamic acid 5-(9-fluorenylmethyl) ester; FMOC-GLUTAMIC ACID-OFM; (S)-5-((9H-Fluoren-9-yl)methoxy)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoic acid
Appearance
White powder
Purity
≥ 98% (HPLC)
Density
1.303±0.06 g/cm3
Melting Point
171-178 °C
Boiling Point
795.3±60.0 °C
Storage
Store at 2-8 °C
InChI
InChI=1S/C34H29NO6/c36-32(37)18-17-31(33(38)40-19-29-25-13-5-1-9-21(25)22-10-2-6-14-26(22)29)35-34(39)41-20-30-27-15-7-3-11-23(27)24-12-4-8-16-28(24)30/h1-16,29-31H,17-20H2,(H,35,39)(H,36,37)/t31-/m0/s1
InChI Key
YDZLVLICRXQATH-HKBQPEDESA-N
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)C(CCC(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

Fmoc-L-glutamic acid α-9-fluorenylmethyl ester is a modified derivative of L-glutamic acid, where the amino group is protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group, and the α-carboxyl group is esterified with a 9-fluorenylmethyl (Fm) group. This compound is commonly used in peptide synthesis, as the Fmoc group provides a protective group for the amino functionality, while the Fm group stabilizes the carboxyl group. The structure of Fmoc-L-glutamic acid α-9-fluorenylmethyl ester enables efficient and selective reactions in peptide chemistry and organic synthesis.

One key application of Fmoc-L-glutamic acid α-9-fluorenylmethyl ester is in peptide synthesis, particularly in the creation of peptides containing modified glutamic acid residues. The Fmoc group allows for selective deprotection under mild conditions, which is useful during the stepwise elongation of peptides. The 9-fluorenylmethyl ester group on the carboxyl group enhances stability during synthesis, ensuring that unwanted side reactions are minimized. This combination of protective groups makes Fmoc-L-glutamic acid α-9-fluorenylmethyl ester an ideal intermediate for synthesizing peptides with specific glutamic acid modifications.

Another important application of Fmoc-L-glutamic acid α-9-fluorenylmethyl ester is in the design of bioactive peptides. By introducing modified glutamic acid residues into peptides, researchers can enhance the stability, solubility, and bioactivity of the resulting molecules. This is particularly useful in the development of therapeutic peptides that target specific receptors or enzymes, as modifications to the glutamic acid side chain can improve binding affinity or reduce susceptibility to enzymatic degradation. Such peptides have applications in drug discovery and the development of targeted therapies for various diseases.

Fmoc-L-glutamic acid α-9-fluorenylmethyl ester is also used in the synthesis of peptide-based materials for drug delivery systems. The stability and compatibility of the Fmoc and 9-fluorenylmethyl ester groups enable the incorporation of this compound into polymeric or hydrogel systems designed for controlled drug release. These materials can encapsulate therapeutic agents and release them in a sustained manner, improving the pharmacokinetics of drugs.

Finally, Fmoc-L-glutamic acid α-9-fluorenylmethyl ester can be used in the synthesis of conjugates, such as peptide-drug conjugates. The stability provided by the Fmoc and 9-fluorenylmethyl ester groups allows for the conjugation of peptides with other biomolecules or therapeutic agents, creating compounds with enhanced specificity and efficacy. These conjugates have significant potential in targeted drug delivery, where the peptide portion directs the therapeutic agent to a specific site in the body, improving the precision and effectiveness of treatments for diseases such as cancer or autoimmune disorders.

1.The in situ synthesis of Ag/amino acid biopolymer hydrogels as mouldable wound dressings.
Zhang Z1, He T1, Yuan M1, Shen R2, Deng L1, Yi L3, Sun Z1, Zhang Y1. Chem Commun (Camb). 2015 Nov 11;51(87):15862-5. doi: 10.1039/c5cc05195a.
This manuscript introduces a one-pot fabrication procedure for the preparation of supramolecular hybrid hydrogels from low-cost commercially available natural products through a "green" strategy. In particular, the hybrid hydrogels, which are developed with Fmoc-Glu-OMe, silver nanoparticles and chitosan, exhibit outstanding antibacterial properties and can be regarded as excellent mouldable wound healing biomaterials.
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