Fmoc-L-glutamic acid γ-tert-butyl ester 4-alkoxybenzyl alcohol resin
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Fmoc-L-glutamic acid γ-tert-butyl ester 4-alkoxybenzyl alcohol resin

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Pre-loaded resins for solid phase peptide and organic synthesis

Category
Wang Resin with Amino Acids
Catalog number
BAT-000068
Synonyms
Fmoc-L-Glu(OtBu)-Wang resin
Appearance
Pale yellow beads
DVB Crosslinking
1% DVB
Mesh Size
100-200 mesh
Substitution
0.3-0.8 meq/g
Storage
Store at 2-8°C

Fmoc-L-glutamic acid γ-tert-butyl ester 4-alkoxybenzyl alcohol resin is a specialized solid-phase resin used in peptide synthesis. It is composed of Fmoc-protected L-glutamic acid, where the γ-carboxyl group is masked with a tert-butyl ester, attached to a 4-alkoxybenzyl alcohol linker on a solid support. This configuration ensures controlled release and selective deprotection, making it suitable for synthesizing complex peptides with side-chain modifications.

A key application of this resin is in solid-phase peptide synthesis (SPPS). Its design facilitates the stepwise assembly of peptides, ensuring high yields and purity. The Fmoc group enables mild removal conditions, while the tert-butyl ester provides stability for the γ-carboxyl group, making it ideal for producing peptides with free carboxyl functionalities.

Another significant use is in the synthesis of cyclic peptides. The resin’s stability allows for on-resin cyclization, a critical step in constructing constrained peptide structures that enhance receptor binding affinity, enzymatic stability, and therapeutic efficacy in drug discovery.

This resin is also widely utilized in synthesizing peptide-drug conjugates (PDCs). Its ability to retain side-chain protection during synthesis ensures compatibility with the introduction of functional payloads, such as cytotoxic drugs or imaging agents, which are essential for targeted therapeutic and diagnostic applications.

Additionally, the resin is valuable in the production of post-translationally modified peptides, such as phosphorylated or glycosylated variants. Its robust linkage system and versatile deprotection strategies enable precise incorporation of modifications, allowing researchers to study peptide structure-function relationships and design biomimetics for pharmaceutical and biochemical research.

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