Fmoc-N-Me-Phe(2-F)-OH
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Fmoc-N-Me-Phe(2-F)-OH

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Category
Fluorinated amino acids
Catalog number
BAT-008737
Molecular Formula
C25H22FNO4
Molecular Weight
419.44
IUPAC Name
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(2-fluorophenyl)propanoic acid
1. Atmospheric Fate of a New Polyfluoroalkyl Building Block, C3F7OCHFCF2SCH2CH2OH
Shira Joudan, John J Orlando, Geoffrey S Tyndall, Teles C Furlani, Cora J Young, Scott A Mabury Environ Sci Technol. 2022 May 17;56(10):6027-6035. doi: 10.1021/acs.est.0c07584. Epub 2021 Apr 22.
Many per- and polyfluoroalkyl substances (PFAS) have been regulated or phased-out of usage due to concerns about persistence, bioaccumulation potential, and toxicity. We investigated the atmospheric fate of a new polyfluorinated alcohol 2-(1,1,2-trifluoro-2-heptafluoropropyloxy-ethylsulfanyl)-ethanol (C3F7OCHFCF2SCH2CH2OH, abbreviated FESOH) by assessing the kinetics and products of the gas-phase reaction of FESOH with chlorine atoms and hydroxyl radicals. Experiments performed in a stainless-steel chamber interfaced to an FTIR were used to determine reaction kinetics and gas-phase products. We report reaction rate constants of k(Cl + FESOH) = (1.5 ± 0.6) × 10-11 cm3 molecule-1 s-1 and k(OH + FESOH) = (4.2 ± 2.0) × 10-12 cm3 molecule-1 s-1. This leads to a calculated FESOH gas-phase lifetime of 2.8 ± 1.3 days with respect to reaction with OH, assuming [OH] = 106 molecule1 cm-3. Gas-phase products of FESOH oxidation included at least two aldehydes, likely C3F7OCHFCF2SCH2C(O)H and C3F7OCHFCF2SC(O)H, and secondary products including COF2, SO2 and C3F7OC(O)F. Additional gas-phase experiments performed in a Teflon chamber were used to assess aqueous products by collecting gaseous samples offline into an aqueous sink prior to analysis with ultrahigh performance liquid chromatography-tandem mass spectrometry, resulting in four acidic products: C3F7OCHFCF2SCH2C(O)OH, C3F7OCHFCF2S(O)(O)OH, C3F7OCHFC(O)OH, and perfluoropropanoic acid (C2F5C(O)OH).
2. Quantitative dynamics of paradigmatic SN2 reaction OH- + CH3F on accurate full-dimensional potential energy surface
Jie Qin, Yang Liu, Jun Li J Chem Phys. 2022 Sep 28;157(12):124301. doi: 10.1063/5.0112228.
The bimolecular reaction between OH- and CH3F is not just a prototypical SN2 process, but it has three other product channels. Here, we develop an accurate full-dimensional potential energy surface (PES) based on 191 193 points calculated at the level CCSD(T)-F12a/aug-cc-pVTZ. A detailed dynamics and mechanism analysis was carried out on this potential energy surface using the quasi-classical trajectory approach. It is verified that the trajectories do not follow the minimum energy path (MEP), but directly dissociate to F- and CH3OH. In addition, a new transition state for proton exchange and a new product complex CH2F-⋯H2O for proton abstraction were discovered. The trajectories avoid the transition state or this complex, instead dissociate to H2O and CH2F- directly through the ridge regions of the minimum energy path before the transition state. These non-MEP dynamics become more pronounced at high collision energies. Detailed dynamic simulations provide new insights into the atomic-level mechanisms of the title reaction, thanks to the new chemically accurate PES, with the aid of machine learning.
3. Synthesis of Polysubstituted Ferrocenesulfoxides
Min Wen, William Erb, Florence Mongin, Yury S Halauko, Oleg A Ivashkevich, Vadim E Matulis, Thierry Roisnel Molecules. 2022 Mar 9;27(6):1798. doi: 10.3390/molecules27061798.
The purpose of the study is to design synthetic methodologies, especially directed deprotometalation using polar organometallic reagents, to access polysubstituted ferrocenesulfoxides. From enantiopure 2-substituted (SiMe3, PPh2) S-tert-butylferrocenesulfoxides, a third substituent was first introduced at the 5 position (SiMe3, I, D, C(OH)Ph2, Me, PPh2, CH2NMe2, F) and removal of the trimethylsilyl group then afforded 2-substituted ferrocenesulfoxides unreachable otherwise. Attempts to apply the "halogen dance" reaction to the ferrocenesulfoxide series led to unexpected results although rationalized in light of calculated pKa values. Further functionalizations were also possible. Thus, new enantiopure, planar chiral di- and trisubstituted ferrocenes have been obtained, in addition to several original 2-substituted, 2,3- and 2,5-disubstituted, 2,3,5-trisubstituted and even 2,3,4,5-tetrasubstituted ferrocenesulfoxides, also enantiopure.
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