Fmoc-piperazine hydrochloride
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Fmoc-piperazine hydrochloride

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Fmoc-piperazine hydrochloride (CAS# 215190-22-0) is a useful research chemical.

Category
Fmoc-Amino Acids
Catalog number
BAT-002008
CAS number
215190-22-0
Molecular Formula
C19H21N2O2Cl
Molecular Weight
344.8
Fmoc-piperazine hydrochloride
IUPAC Name
9H-fluoren-9-ylmethyl piperazine-1-carboxylate;hydrochloride
Synonyms
Fmoc-Piz HCl
Purity
> 98 %
Storage
Store at 2-8 ℃
InChI
InChI=1S/C19H20N2O2.ClH/c22-19(21-11-9-20-10-12-21)23-13-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18;/h1-8,18,20H,9-13H2;1H
InChI Key
IXWMXZSFRQQDDO-UHFFFAOYSA-N
Canonical SMILES
C1CN(CCN1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24.Cl
1. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
2. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
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