Fmoc-S-trityl-D-cysteine (BAT-003840)
* For research use only

Category
Fmoc-Amino Acids
Catalog number
BAT-003840
CAS number
167015-11-4
Molecular Formula
C37H31NO4S
Molecular Weight
585.70
Fmoc-S-trityl-D-cysteine
Synonyms
Fmoc-D-Cys(Trt)-OH; Fmoc-S-trityl-D-cysteine; N-Fmoc-S-trityl-D-cysteine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-D-cysteine
Appearance
White powder
Purity
≥ 99.9% (HPLC, Chiral purity)
Density
1.270±0.06 g/cm3
Melting Point
170-180 °C
Boiling Point
763.4±60.0 °C
Storage
Store at 2-8 °C
1.A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications.
Bergeron ZL1, Chun JB, Baker MR, Sandall DW, Peigneur S, Yu PY, Thapa P, Milisen JW, Tytgat J, Livett BG, Bingham JP. Peptides. 2013 Nov;49:145-58. doi: 10.1016/j.peptides.2013.09.004. Epub 2013 Sep 18.
Cone snail venoms provide a largely untapped source of novel peptide drug leads. To enhance the discovery phase, a detailed comparative proteomic analysis was undertaken on milked venom from the mollusk-hunting cone snail, Conus textile, from three different geographic locations (Hawai'i, American Samoa and Australia's Great Barrier Reef). A novel milked venom conopeptide rich in post-translational modifications was discovered, characterized and named α-conotoxin TxIC. We assign this conopeptide to the 4/7 α-conotoxin family based on the peptide's sequence homology and cDNA pre-propeptide alignment. Pharmacologically, α-conotoxin TxIC demonstrates minimal activity on human acetylcholine receptor models (100 μM, <5% inhibition), compared to its high paralytic potency in invertebrates, PD50 = 34.2 nMol kg(-1). The non-post-translationally modified form, [Pro](2,8)[Glu](16)α-conotoxin TxIC, demonstrates differential selectivity for the α3β2 isoform of the nicotinic acetylcholine receptor with maximal inhibition of 96% and an observed IC50 of 5.
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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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