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(Gln22,Asn23)-Amyloid β-Protein (1-40)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

(Gln22,Asn23)-Amyloid β-Protein (1-40) is a transgenic mice expressing vasculotropic Dutch/Iowa (E693Q/D694N) mutant human brain Aβ precursor protein (TG-SWDI), which accumulates abundant cerebral microvascular fibrillar amyloid deposition and exhibits strong neuroinflammation. In vitro, double-mutated Aβ peptides showed a tendency to increase fibrillation and pathogenicity compared with Dutch and Iowa single mutants.

Category

Functional Peptides

Catalog number

BAT-014663

CAS number

374796-75-5

Molecular Formula

C194H297N55O56S

Molecular Weight

4327.82

Specification

Synonyms

Amyloid β-Protein (1-40) E22Q/D23N; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asn-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

Appearance

White Powder

Purity

≥95%

Sequence

DAEFRHDSGYEVHHQKLVFFAQNVGSNKGAIIGLMVGGVV

Storage

Store at -20°C

Solubility

Soluble in Acetonitrile, Water