(Gly22)-Amyloid β-Protein (1-40)
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(Gly22)-Amyloid β-Protein (1-40)

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(Gly22)-Amyloid β-Protein (1-40) is a highly neurotoxic Aβ arctic mutant (E22G) that has been used to study the mechanism underlying of soluble and insoluble β-amyloid aggregation formation. As wild-type Aβ, it preferably assembles in the presence of GM1 ganglioside.

Category
Functional Peptides
Catalog number
BAT-015249
CAS number
175010-18-1
Molecular Formula
C191H291N53O56S
Molecular Weight
4257.74
(Gly22)-Amyloid β-Protein (1-40)
IUPAC Name
(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]propanoyl]amino]-5-oxopentanoic acid
Synonyms
Amyloid β-Protein (1-40) E22G; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gly-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-glycyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valine
Appearance
White Lyophilized Powder
Purity
≥95%
Sequence
DAEFRHDSGYEVHHQKLVFFAGDVGSNKGAIIGLMVGGVV
Storage
Store at -20°C
Solubility
Soluble in Water
InChI
InChI=1S/C191H291N53O56S/c1-25-101(19)156(185(294)209-86-142(254)216-122(65-93(3)4)171(280)226-121(60-64-301-24)169(278)238-150(95(7)8)183(292)207-81-138(250)203-82-144(256)237-152(97(11)12)188(297)242-155(100(17)18)190(299)300)244-189(298)157(102(20)26-2)243-160(269)104(22)213-139(251)83-205-162(271)115(47-36-38-61-192)221-178(287)131(75-137(196)249)232-182(291)135(89-246)219-143(255)87-208-184(293)151(96(9)10)239-181(290)132(76-148(263)264)218-140(252)84-204-158(267)103(21)215-170(279)125(67-106-41-30-27-31-42-106)229-174(283)127(69-108-45-34-29-35-46-108)234-186(295)154(99(15)16)241-180(289)123(66-94(5)6)227-164(273)116(48-37-39-62-193)222-166(275)118(54-57-136(195)248)224-175(284)128(71-110-78-199-90-210-110)231-177(286)130(73-112-80-201-92-212-112)235-187(296)153(98(13)14)240-168(277)120(56-59-146(259)260)225-172(281)124(70-109-50-52-113(247)53-51-109)217-141(253)85-206-163(272)134(88-245)236-179(288)133(77-149(265)266)233-176(285)129(72-111-79-200-91-211-111)230-165(274)117(49-40-63-202-191(197)198)223-173(282)126(68-107-43-32-28-33-44-107)228-167(276)119(55-58-145(257)258)220-159(268)105(23)214-161(270)114(194)74-147(261)262/h27-35,41-46,50-53,78-80,90-105,114-135,150-157,245-247H,25-26,36-40,47-49,54-77,81-89,192-194H2,1-24H3,(H2,195,248)(H2,196,249)(H,199,210)(H,200,211)(H,201,212)(H,203,250)(H,204,267)(H,205,271)(H,206,272)(H,207,292)(H,208,293)(H,209,294)(H,213,251)(H,214,270)(H,215,279)(H,216,254)(H,217,253)(H,218,252)(H,219,255)(H,220,268)(H,221,287)(H,222,275)(H,223,282)(H,224,284)(H,225,281)(H,226,280)(H,227,273)(H,228,276)(H,229,283)(H,230,274)(H,231,286)(H,232,291)(H,233,285)(H,234,295)(H,235,296)(H,236,288)(H,237,256)(H,238,278)(H,239,290)(H,240,277)(H,241,289)(H,242,297)(H,243,269)(H,244,298)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,299,300)(H4,197,198,202)/t101-,102-,103-,104-,105-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,150-,151-,152-,153-,154-,155-,156-,157-/m0/s1
InChI Key
HREHWFHVRHRTCT-FEPTUWFISA-N
Canonical SMILES
CCC(C)C(C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)CNC(=O)C(C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)N)NC(=O)C(CC3=CN=CN3)NC(=O)C(CC4=CN=CN4)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC6=CN=CN6)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)N
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