H-D-Phe(4-NO2)-OMe HCl (BAT-004831)
* For research use only

Category
D-Amino Acids
Catalog number
BAT-004831
CAS number
67877-95-6
Molecular Formula
C10H12N2O4·HCl
Molecular Weight
260.7
H-D-Phe(4-NO2)-OMe HCl
Synonyms
(r)-2-amino-2-(4-chlorophenyl)acetic acid; (R)-4-Chlorophenylglycine
Purity
95%
Density
1.392±0.06 g/cm3(Predicted)
Melting Point
272-274 °C
Boiling Point
328.8±32.0 °C(Predicted)
Storage
Store at 2-8°C
1.Fate and transport with material response characterization of green sorption media for copper removal via desorption process.
Chang NB1, Houmann C2, Lin KS3, Wanielista M2. Chemosphere. 2016 Apr 12;154:444-453. doi: 10.1016/j.chemosphere.2016.03.130. [Epub ahead of print]
Multiple adsorption and desorption cycles are required to achieve the reliable operation of copper removal and recovery. A green sorption media mixture composed of recycled tire chunk, expanded clay aggregate, and coconut coir was evaluated in this study for its desorptive characteristics as a companion study of the corresponding adsorption process in an earlier publication. We conducted a screening of potential desorbing agents, batch desorption equilibrium and kinetic studies, and batch tests through 3 adsorption/desorption cycles. The desorbing agent screening revealed that hydrochloric acid has good potential for copper desorption. Equilibrium data fit the Freundlich isotherm, whereas kinetic data had high correlation with the Lagergren pseudo second-order model and revealed a rapid desorption reaction. Batch equilibrium data over 3 adsorption/desorption cycles showed that the coconut coir and media mixture were the most resilient, demonstrating they could be used through 3 or more adsorption/desorption cycles.
2.New antiviral targets for innovative treatment concepts for hepatitis B virus and hepatitis delta virus.
Durantel D1, Zoulim F2. J Hepatol. 2016 Apr;64(1 Suppl):S117-31. doi: 10.1016/j.jhep.2016.02.016.
Current therapies of chronic hepatitis B (CHB) remain limited to pegylated-interferon-alpha (PegIFN-α) or any of the five approved nucleos(t)ide analogues (NUC) treatments. While viral suppression can be achieved in the majority of patients with the high-barrier-to-resistance new-generation of NUC, i.e. entecavir and tenofovir, HBsAg loss is achieved by PegIFN-α and/or NUC in only 10% of patients, after a 5-year follow-up. Attempts to improve the response by administering two different NUC or a combination of NUC and PegIFN-α have not provided a dramatic increase in the rate of functional cure. Because of this and the need of long-term NUC administration, there is a renewed interest regarding the understanding of various steps of the HBV replication cycle, as well as specific virus-host cell interactions, in order to define new targets and develop new antiviral drugs. This includes a direct inhibition of viral replication with entry inhibitors, drugs targeting cccDNA, siRNA targeting viral transcripts, capsid assembly modulators, and approaches targeting the secretion of viral envelope proteins.
3.DFT and experimental study on the mechanism of elemental mercury capture in the presence of HCl on α-Fe2O3 (001).
Liu T, Xue L, Guo X, Huang Y, Zheng C. Environ Sci Technol. 2016 Apr 15. [Epub ahead of print]
To investigate the mechanism of Hg0 adsorption on α-Fe2O3 (001) surface in the presence of HCl, which was considered to be beneficial for Hg0 removal, theoretical calculations based on density functional theory as well as corresponding experiments were carried out. HCl adsorption was firstly performed on α-Fe2O3(001) surface, and the Hg0 adsorption on HCl-adsorbed α-Fe2O3(001) surface was subsequently researched, demonstrating that HCl dissociates on the surface of α-Fe2O3, improving the Hg0 adsorption reactivity. With further chlorination of α-Fe2O3(001) surface, the FeCl3 could be achieved and the adsorption energy of Hg0 on FeCl3 surface reaches -104.2 kJ/mol, belonging to strong chemisorption. Meanwhile, a group of designed experiments, including the Hg0 adsorption on HCl pre-adsorbed α-Fe2O3 as well as the co-adsorption of both gaseous components, were respectively performed to explore the pathways of Hg0 transformation. Combining computational and experimental results together, the Eley-Rideal mechanism with HCl pre-adsorption can be determined.
4.Mucosal acidification increases hydrogen sulfide release through up-regulating gene and protein expressions of cystathionine gamma-lyase in the rat gastric mucosa.
Mard SA1, Veisi A2, Ahangarpour A2, Gharib-Naseri MK2. Iran J Basic Med Sci. 2016 Feb;19(2):172-7.
OBJECTIVES: This study was performed to investigate the effects of mucosal acidification on mRNA expression and protein synthesis of cystathionine gamma lyase (CSE), cystathionine beta synthase (CBS), and mucosal release of H2S in gastric mucosa in rats.
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