H-DL-Ala-OMe HCl
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H-DL-Ala-OMe HCl

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Category
DL-Amino Acids
Catalog number
BAT-003615
CAS number
13515-97-4
Molecular Formula
C4H9NO2·HCl
Molecular Weight
139.60
H-DL-Ala-OMe HCl
IUPAC Name
methyl 2-aminopropanoate;hydrochloride
Synonyms
DL-Alanine methyl ester hydrochloride; DL-2-Aminopropionic acid methyl ester hydrochloride; H-DL-Ala-Ome HCl; methyl 2-aminopropanoate hydrochloride; Methyl 2-aminopropanoate hydrochloride
Appearance
White powder
Purity
≥ 99% (HPLC)
Density
1.01 g/cm3
Melting Point
154-156 °C
Boiling Point
101.5 °C at 760 mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C4H9NO2.ClH/c1-3(5)4(6)7-2;/h3H,5H2,1-2H3;1H
InChI Key
IYUKFAFDFHZKPI-UHFFFAOYSA-N
Canonical SMILES
CC(C(=O)OC)N.Cl

H-DL-Ala-OMe HCl (alpha-DL-alanine methyl ester hydrochloride) is a versatile biochemical reagent utilized across diverse research and industrial realms. Below are detailed applications of H-DL-Ala-OMe HCl presented with a high degree of perplexity and burstiness:

Peptide Synthesis: Acting as a shielded form of alanine, H-DL-Ala-OMe HCl finds common application in peptide and protein synthesis. Its role in building intricate peptides for biochemical and pharmaceutical exploration is crucial, as it seamlessly integrates into peptide chains without triggering undesired reactions, streamlining the synthesis process.

Enzyme Kinetics: Scientists leverage H-DL-Ala-OMe HCl to delve into enzyme kinetics and substrate specificity, serving as a foundational substrate for various enzymes like esterases and proteases. This enables a comprehensive analysis of enzymatic activities, shedding light on enzyme mechanisms, and aiding in the design of enzyme inhibitors for potential therapeutic use.

Medicinal Chemistry: In the realm of medicinal chemistry, H-DL-Ala-OMe HCl acts as a pivotal precursor for the synthesis of pharmaceutical compounds. By providing a readily available alanine source, it facilitates the development of novel drug candidates, particularly in the creation of small molecules targeting specific biological pathways, advancing drug discovery and development.

Protein Engineering: Exploring protein engineering, H-DL-Ala-OMe HCl enables the introduction of alanine residues into proteins through site-directed mutagenesis. Researchers can tailor protein properties such as stability, activity, and binding affinity by modifying the amino acid sequence, paving the way for the creation of proteins with desired functionalities for therapeutic and industrial applications, showcasing the versatility and utility of this biochemical reagent.

1. Superconcentrated hydrochloric acid
Kun Huang, et al. J Phys Chem B. 2011 Jun 23;115(24):7823-9. doi: 10.1021/jp109551z. Epub 2011 May 26.
We report the discovery of a potentially useful superconcentrated HCl at ambient temperature and pressure by using a simple surfactant-based reversed micelle system. Surprisingly, the molar ratios of H(+) to H(2)O (denoted as n(H+)/n(H2O)) in superconcentrated HCl can be larger than 5, while the maximum achievable n(H+)/n(H2O) value for conventional saturated HCl aqueous solution (37 wt %) is only about 0.28. Furthermore, both NMR and FT-IR results indicate that a significant amount of HCl remains in the molecular form rather than being ionized into H(+) and Cl(-). The superconcentrated HCl may promote some organic reactions that are not feasible by using conventional 37 wt % HCl solution. For example, addition reaction between C═C and HCl occurs in superconcentrated HCl solution without using catalysts.
2. Standardized Hybrid Closed-Loop System Reporting
Viral N Shah, Satish K Garg Diabetes Technol Ther. 2021 May;23(5):323-331. doi: 10.1089/dia.2020.0622. Epub 2020 Nov 25.
The hybrid closed-loop (HCL) system has been shown to improve glycemic control and reduce hypoglycemia. Optimization of HCL settings requires interpretation of the glucose, insulin, and factors affecting glucose such as food intake and exercise. To the best of our knowledge, there is no published guidance on the standardized reporting of HCL systems. Standardization of HCL reporting would make interpretation of data easy across different systems. We reviewed the literature on patient and provider perspectives on downloading and reporting glucose metric preferences. We also incorporated international consensus on standardized reporting for glucose metrics. We describe a single-page HCL data reporting, referred to here as "artificial pancreas (AP) Dashboard." We propose seven components in the AP Dashboard that can provide detailed information and visualization of glucose, insulin, and HCL-specific metrics. The seven components include (A) glucose metrics, (B) hypoglycemia, (C) insulin, (D) user experience, (E) hyperglycemia, (F) glucose modal-day profile, and (G) insight. A single-page report similar to an electrocardiogram can help providers and patients interpret HCL data easily and take the necessary steps to improve glycemic outcomes. We also describe the optimal sampling duration for HCL data download and color coding for visualization ease. We believe that this is a first step in creating a standardized HCL reporting, which may result in better uptake of the systems. For increased adoption, standardized reporting will require input from providers, patients, diabetes device manufacturers, and regulators.
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