H-Glu(EDANS)-Lys-Pro-Ala-Lys-Phe-Phe-Arg-Leu-Lys(DABCYL)-NH2
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H-Glu(EDANS)-Lys-Pro-Ala-Lys-Phe-Phe-Arg-Leu-Lys(DABCYL)-NH2

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H-Glu(EDANS)-Lys-Pro-Ala-Lys-Phe-Phe-Arg-Leu-Lys(DABCYL)-NH2 is a quenched fluorescent (FRET) substrate for ADAM 8, ADAM 15 and MDC-L (ADAM 28) but not for ADAM 17. For ADAM 8 half maximal cleavage was observed at 2.5 µM.

Category
Others
Catalog number
BAT-014524
CAS number
1926163-42-9
Molecular Formula
C88H124N22O15S
Molecular Weight
1762.12
IUPAC Name
5-[2-[[(4S)-4-amino-5-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-6-[[4-[[4-(dimethylamino)phenyl]diazenyl]benzoyl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-5-oxopentanoyl]amino]ethylamino]naphthalene-1-sulfonic acid
Synonyms
L-Lysinamide, N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-glutaminyl-L-lysyl-L-prolyl-L-alanyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucyl-N6-[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]-; 5-((2-((S)-4-amino-5-(((S)-6-amino-1-((S)-2-(((7S,10S,13S,16S,19S,22S,25S)-22-(4-aminobutyl)-16,19-dibenzyl-7-carbamoyl-1-(4-((E)-(4-(dimethylamino)phenyl)diazenyl)phenyl)-13-(3-guanidinopropyl)-10-isobutyl-1,9,12,15,18,21,24-heptaoxo-2,8,11,14,17,20,23-heptaazahexacosan-25-yl)carbamoyl)pyrrolidin-1-yl)-1-oxohexan-2-yl)amino)-5-oxopentanamido)ethyl)amino)naphthalene-1-sulfonic acid
Appearance
Red Lyophilized Powder
Purity
≥95%
Density
1.36±0.1 g/cm3
Sequence
E(EDANS)KPAKFFRLK(DABCYL)-NH2
Storage
Store at -20°C
Solubility
Soluble in Water
InChI
InChI=1S/C88H124N22O15S/c1-55(2)52-71(83(118)100-67(77(92)112)28-14-17-47-97-79(114)59-35-37-60(38-36-59)107-108-61-39-41-62(42-40-61)109(4)5)104-82(117)69(32-20-48-98-88(93)94)102-84(119)72(53-57-22-8-6-9-23-57)106-85(120)73(54-58-24-10-7-11-25-58)105-81(116)68(29-12-15-45-89)101-78(113)56(3)99-86(121)74-33-21-51-110(74)87(122)70(30-13-16-46-90)103-80(115)65(91)43-44-76(111)96-50-49-95-66-31-18-27-64-63(66)26-19-34-75(64)126(123,124)125/h6-11,18-19,22-27,31,34-42,55-56,65,67-74,95H,12-17,20-21,28-30,32-33,43-54,89-91H2,1-5H3,(H2,92,112)(H,96,111)(H,97,114)(H,99,121)(H,100,118)(H,101,113)(H,102,119)(H,103,115)(H,104,117)(H,105,116)(H,106,120)(H4,93,94,98)(H,123,124,125)/t56-,65-,67-,68-,69-,70-,71-,72-,73-,74-/m0/s1
InChI Key
PICIJFXRVFBIHA-OXWHXMHOSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(CCCCNC(=O)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)N(C)C)C(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CCCCN)NC(=O)C(CCC(=O)NCCNC6=CC=CC7=C6C=CC=C7S(=O)(=O)O)N
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