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Application Area

H-N-Me-Ala-OH HCl

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category

L-Amino Acids

Catalog number

BAT-000869

CAS number

65672-32-4

Molecular Formula

C4H9NO2·HCl

Molecular Weight

139.6

IUPAC Name

(2S)-2-(methylamino)propanoic acid;hydrochloride

Synonyms

N-Alpha-Methyl-L-Alanine hydrochloride; (S)-2-(Methylamino)propanoic acid hydrochloride

Related CAS

3913-67-5 (free base)

Purity

95%

Storage

Store at 2-8 °C

InChI

InChI=1S/C4H9NO2.ClH/c1-3(5-2)4(6)7;/h3,5H,1-2H3,(H,6,7);1H/t3-;/m0./s1

InChI Key

QYXBNPBZWXNBGN-DFWYDOINSA-N

Canonical SMILES

CC(C(=O)O)NC.Cl

H-N-Me-Ala-OH HCl, a synthesized compound extensively utilized in diverse biochemical and pharmaceutical investigations, has a multitude of applications. Here are the key applications presented with high perplexity and burstiness:

Peptide Synthesis: Serving as a foundational component in peptide and protein synthesis, H-N-Me-Ala-OH HCl plays a pivotal role in crafting peptides with enhanced stability and resistance to enzymatic breakdown. This attribute is invaluable in the development of therapeutic peptides and in advancing biochemical research, propelling discoveries in the realm of biomolecular design.

Protease Inhibition Studies: Delving into the intricate world of protease enzyme inhibition, researchers employ H-N-Me-Ala-OH HCl to explore the dynamics of protease inhibitors. By integrating this compound into peptide substrates, scientists can assess the efficacy and specificity of protease inhibitors, a critical step in the creation of drugs targeting protease-associated diseases like HIV and cancer, unveiling new avenues in the fight against these conditions.

Molecular Modeling: Acting as a cornerstone in computational investigations, H-N-Me-Ala-OH HCl serves as a scaffold for studying peptide conformations and interactions. Its utilization in molecular dynamics simulations allows researchers to forecast how peptides behave in diverse environments, yielding invaluable insights essential for drug development and unlocking the mysteries surrounding protein folding and functionality, navigating the complex landscape of molecular biology.

Analytical Chemistry: In the realm of analytical chemistry, H-N-Me-Ala-OH HCl finds widespread application as an internal standard or calibration compound, ensuring precise quantification and analysis in various chromatographic and spectroscopic methodologies. Leveraging its well-defined chemical properties, this compound guarantees accuracy and reliability in biochemical assays, setting the gold standard for consistency in analytical studies and fostering advancements in the field of chemical analysis.

1. Superconcentrated hydrochloric acid

Kun Huang, et al. J Phys Chem B. 2011 Jun 23;115(24):7823-9. doi: 10.1021/jp109551z. Epub 2011 May 26.

We report the discovery of a potentially useful superconcentrated HCl at ambient temperature and pressure by using a simple surfactant-based reversed micelle system. Surprisingly, the molar ratios of H(+) to H(2)O (denoted as n(H+)/n(H2O)) in superconcentrated HCl can be larger than 5, while the maximum achievable n(H+)/n(H2O) value for conventional saturated HCl aqueous solution (37 wt %) is only about 0.28. Furthermore, both NMR and FT-IR results indicate that a significant amount of HCl remains in the molecular form rather than being ionized into H(+) and Cl(-). The superconcentrated HCl may promote some organic reactions that are not feasible by using conventional 37 wt % HCl solution. For example, addition reaction between C═C and HCl occurs in superconcentrated HCl solution without using catalysts.

2. Standardized Hybrid Closed-Loop System Reporting

Viral N Shah, Satish K Garg Diabetes Technol Ther. 2021 May;23(5):323-331. doi: 10.1089/dia.2020.0622. Epub 2020 Nov 25.

The hybrid closed-loop (HCL) system has been shown to improve glycemic control and reduce hypoglycemia. Optimization of HCL settings requires interpretation of the glucose, insulin, and factors affecting glucose such as food intake and exercise. To the best of our knowledge, there is no published guidance on the standardized reporting of HCL systems. Standardization of HCL reporting would make interpretation of data easy across different systems. We reviewed the literature on patient and provider perspectives on downloading and reporting glucose metric preferences. We also incorporated international consensus on standardized reporting for glucose metrics. We describe a single-page HCL data reporting, referred to here as "artificial pancreas (AP) Dashboard." We propose seven components in the AP Dashboard that can provide detailed information and visualization of glucose, insulin, and HCL-specific metrics. The seven components include (A) glucose metrics, (B) hypoglycemia, (C) insulin, (D) user experience, (E) hyperglycemia, (F) glucose modal-day profile, and (G) insight. A single-page report similar to an electrocardiogram can help providers and patients interpret HCL data easily and take the necessary steps to improve glycemic outcomes. We also describe the optimal sampling duration for HCL data download and color coding for visualization ease. We believe that this is a first step in creating a standardized HCL reporting, which may result in better uptake of the systems. For increased adoption, standardized reporting will require input from providers, patients, diabetes device manufacturers, and regulators.