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Application Area

H-N-Me-D-Ala-OH HCl

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category

D-Amino Acids

Catalog number

BAT-000870

Molecular Formula

C4H9NO2·HCl

Molecular Weight

139.6

Synonyms

N-Alpha-Methyl-D-Alanine hydrochloride; (R)-2-(Methylamino)propanoic acid hydrochloride

Storage

Store at 2-8 °C

H-N-Me-D-Ala-OH HCl, a derivative molecule of alanine with distinct properties, finds diverse applications in bioscience. Here are the key applications presented with high perplexity and burstiness:

Peptide Synthesis: An indispensable component in synthesizing synthetic peptides, H-N-Me-D-Ala-OH HCl serves as a foundational unit. Its incorporation into peptide sequences enables researchers to explore protein-protein interactions and craft novel peptides with tailored biological activities. This compound plays a pivotal role in developing therapeutic peptides and unraveling enzyme-substrate dynamics.

Pharmacological Research: Within the realm of drug discovery, H-N-Me-D-Ala-OH HCl plays a crucial role in generating peptide-based drugs and inhibitors. By modifying peptide backbones, researchers enhance binding affinities and stability of molecules, aiding in the creation of drugs targeting specific enzymes or receptors involved in various diseases. This compound drives the design of innovative therapeutic solutions.

Enzyme Study: Serving as a substrate or inhibitor in enzymatic investigations, H-N-Me-D-Ala-OH HCl sheds light on enzyme mechanisms. Incorporating this molecule into enzyme assays enables scientists to decipher how structural alterations in substrates influence enzyme activity. This deepens comprehension of enzyme specificity and functionality, benefiting both foundational research and clinical practices.

Drug Delivery Systems: Integral to advanced drug delivery systems, H-N-Me-D-Ala-OH HCl contributes to achieving precise and controlled drug release. By integrating it into polymeric carriers or nanoparticles, targeted delivery of therapeutic agents is facilitated, enhancing efficacy and safety profiles of drugs, particularly in chronic disease treatments. This application underscores the importance of tailored drug delivery mechanisms in improving patient outcomes.

1. Standardized Hybrid Closed-Loop System Reporting

Viral N Shah, Satish K Garg Diabetes Technol Ther. 2021 May;23(5):323-331. doi: 10.1089/dia.2020.0622. Epub 2020 Nov 25.

The hybrid closed-loop (HCL) system has been shown to improve glycemic control and reduce hypoglycemia. Optimization of HCL settings requires interpretation of the glucose, insulin, and factors affecting glucose such as food intake and exercise. To the best of our knowledge, there is no published guidance on the standardized reporting of HCL systems. Standardization of HCL reporting would make interpretation of data easy across different systems. We reviewed the literature on patient and provider perspectives on downloading and reporting glucose metric preferences. We also incorporated international consensus on standardized reporting for glucose metrics. We describe a single-page HCL data reporting, referred to here as "artificial pancreas (AP) Dashboard." We propose seven components in the AP Dashboard that can provide detailed information and visualization of glucose, insulin, and HCL-specific metrics. The seven components include (A) glucose metrics, (B) hypoglycemia, (C) insulin, (D) user experience, (E) hyperglycemia, (F) glucose modal-day profile, and (G) insight. A single-page report similar to an electrocardiogram can help providers and patients interpret HCL data easily and take the necessary steps to improve glycemic outcomes. We also describe the optimal sampling duration for HCL data download and color coding for visualization ease. We believe that this is a first step in creating a standardized HCL reporting, which may result in better uptake of the systems. For increased adoption, standardized reporting will require input from providers, patients, diabetes device manufacturers, and regulators.

2. Superconcentrated hydrochloric acid

Kun Huang, et al. J Phys Chem B. 2011 Jun 23;115(24):7823-9. doi: 10.1021/jp109551z. Epub 2011 May 26.

We report the discovery of a potentially useful superconcentrated HCl at ambient temperature and pressure by using a simple surfactant-based reversed micelle system. Surprisingly, the molar ratios of H(+) to H(2)O (denoted as n(H+)/n(H2O)) in superconcentrated HCl can be larger than 5, while the maximum achievable n(H+)/n(H2O) value for conventional saturated HCl aqueous solution (37 wt %) is only about 0.28. Furthermore, both NMR and FT-IR results indicate that a significant amount of HCl remains in the molecular form rather than being ionized into H(+) and Cl(-). The superconcentrated HCl may promote some organic reactions that are not feasible by using conventional 37 wt % HCl solution. For example, addition reaction between C═C and HCl occurs in superconcentrated HCl solution without using catalysts.