H-Nva-OMe HCl (BAT-002108)
* For research use only

Category
L-Amino Acids
Catalog number
BAT-002108
CAS number
56558-30-6
Molecular Formula
C6H13NO2·HCl
Molecular Weight
167.6
H-Nva-OMe HCl
Synonyms
(S)-Methyl 2-aminopentanoate hydrochloride
Appearance
Off-white to white solid
Purity
99%
Density
g/cm3
Boiling Point
197.5ºC at 760mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C6H13NO2.ClH/c1-3-4-5(7)6(8)9-2;/h5H,3-4,7H2,1-2H3;1H/t5-;/m0./s1
InChI Key
IODNYRVZHKRFIW-JEDNCBNOSA-N
Canonical SMILES
CCCC(C(=O)OC)N.Cl
1.Fluorescent detection and imaging of Hg(2+) using a novel phenanthroline derivative based single- and two-photon excitation.
Zhang X1, Li LL2, Liu YK2. Mater Sci Eng C Mater Biol Appl. 2016 Feb 1;59:916-23. doi: 10.1016/j.msec.2015.10.080. Epub 2015 Oct 30.
A novel phenanthroline derivative, 4-[4-(N-methyl)styrene]-imidazo[4,5-f][1,10]phenanthroline-benzene iodated salt (MSIPBI), was synthesized, and the linear absorption and fluorescent spectra of MSIPBI in different solvents were investigated. The photophysical properties in unbound and in ligand-metal complexes were evaluated by UV absorption and one- and two-photon fluorescent spectra, and the quantum yields, two-photon active cross-sections and the binding constant of dye-metal were calculated. The results indicated that MSIPBI has a large Stokes shift (more than 167nm), and the dye was selective and sensitive for the detection of Hg(2+) with a two-photon active cross-section of 55.5GM in tris-HCl buffer solution at 800nm. Furthermore, the results of the fluorescence microscopy imaging indicated that MSIPBI is an efficient fluorescent probe for the detection of Hg(2+) in living cells by one- and two-photon excitation. Moreover, the experiments of determination Hg(2+) in river water and tap water were finished.
2.Nano Spray Drying Technique as a Novel Approach To Formulate Stable Econazole Nitrate Nanosuspension Formulations for Ocular Use.
Maged A1, Mahmoud AA1,2, Ghorab MM3. Mol Pharm. 2016 Mar 31. [Epub ahead of print]
The effect of using methyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin as carriers for econazole nitrate nanoparticles prepared by nano spray dryer was explored in this work. Stabilizers, namely, poly(ethylene oxide), polyvinylpyrrolidone k30, poloxamer 407, Tween 80, and Cremophor EL, were used. The nano spray dried formulations revealed almost spherical particles with an average particle size values ranging from 121 to 1565 nm and zeta potential values ranging from -0.8 to -2.5 mV. The yield values for the obtained formulations reached 80%. The presence of the drug in the amorphous state within the nanosuspension matrix system significantly improved drug release compared to that for pure drug. Combination of hydroxypropyl-β-cyclodextrin with Tween 80 achieved an important role for preserving the econazole nanosuspension from aggregation during storage for one year at room temperature as well as improving drug release from the nanosuspension.
3.[A Study on Preparation and Photocatalytic Activity of Mn-BiOCl].
Cui YM, Li HQ, Miao H, Tao DL, Fan SH, Zhang K, Huo XF. Guang Pu Xue Yu Guang Pu Fen Xi. 2015 Jul;35(7):1997-2000.
Using Bi2O3 and MnC2 x 4H2O as raw materials, with HCl as solvent, photocatalysts of Mn-BiOCl with different molar ratio of Mn and Bi were prepared by a hydrolysis method. The obtained samples were characterized by XRD, HRTEM, TEM, UV-Vis DRS and SPS. The UV light photocatalytic activity of Mn-BiOCl was evaluated by using methyl orange as model compounds of photocatalytic reaction. The active species in the degradation process of methyl orange were studied. The results show that the Mn content of Mn-BiOCl photocatalysts has an important effect on the catalytic activity. When the molar ratio of Mn and Bi is 0.25%, the as-prepared Mn-BiOCl photocatalyst has the highest catalytic activity toward the degradation of methyl orange. Photocatalytic degradation rate of methyl orange can reach 95.1%.
4.Dynamical Properties of N-Isopropylacrylamide Molecule in Water Revealed by (1)H NMR Studies.
Sasaki S1. J Phys Chem B. 2016 Jan 14;120(1):184-92. doi: 10.1021/acs.jpcb.5b09879. Epub 2015 Dec 31.
The hydration of alkyl-amide molecules in water is very important for understanding their solubility in water, which related to the phase behavior of polyamides including protein molecules in water. The (1)H NMR signals of N-isopropylacrylamide (NIPA) in water were investigated for the purpose to reveal the hydration properties of NIPA in the aqueous HCl solutions, which change the phase behavior of aqueous NIPA solutions with HCl concentration as reported previously (J. Phys. Chem. B 2011, 115, 12905-12910). The following observations were revealed by the present studies. (1) The spin-spin coupling of the amide proton with the methyne proton in the HCl solution was observed when a half width of amide peak (∼Δν) was less than about 10 Hz, but it was not when Δν was greater than 10 Hz. (2) The Δν value of amide proton increased with an increase in a mole ratio of H2O to NIPA (rH2O) or with enlargement of the protonated hydration shell, which reduced the energy gap of the cis- and trans-conformations.
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