H-TYR-TYR-OH
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H-TYR-TYR-OH

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Tyr-Tyr and Tyr-Tyr-Tyr efficiently inhibit angiotensin I-converting enzyme (ACE) from rabbit lung, their IC50 values were 34 μM and 51 μM, respectively. These two tyrosine peptides exhibited a mix of competitive and noncompetitive inhibitions.

Category
Peptide Inhibitors
Catalog number
BAT-015892
CAS number
1050-28-8
Molecular Formula
C18H20N2O5
Molecular Weight
344.36
H-TYR-TYR-OH
IUPAC Name
(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
Synonyms
Tyr-tyr; Tyrosyltyrosine; L-Tyrosyl-L-tyrosine; Peptide tyrosine-tyrosine; L-Tyr-L-Tyr; N-L-tyrosyl-L-tyrosine
Purity
95%
Sequence
H-Tyr-Tyr-OH
InChI
InChI=1S/C18H20N2O5/c19-15(9-11-1-5-13(21)6-2-11)17(23)20-16(18(24)25)10-12-3-7-14(22)8-4-12/h1-8,15-16,21-22H,9-10,19H2,(H,20,23)(H,24,25)/t15-,16-/m0/s1
InChI Key
JAQGKXUEKGKTKX-HOTGVXAUSA-N
Canonical SMILES
C1=CC(=CC=C1CC(C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)N)O
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