Need Assistance?
  • US & Canada:
  • UK: +


* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

L-alanine is a non-essential amino acid involved in the metabolism of tryptophan and vitamin pyridoxine.

L-Amino Acids
Catalog number
CAS number
Molecular Formula
Molecular Weight
(2S)-2-aminopropanoic acid
Alanine; (S)-Alanine; H-Ala-OH; Alanine, L-; (2S)-2-Azaniumylpropanoate; (S)-(+)-Alanine; (S)-2-Aminopropanoic acid; L-(+)-Alanine; L-2-Aminopropanoic acid; L-2-Aminopropionic acid; L-α-Alanine; L-α-Aminopropionic acid; Lactamine; NSC 206315; Propanoic acid, 2-amino-, (S)-; α-Alanine; α-Aminopropionic acid
Related CAS
6898-94-8 (Deleted CAS) 115967-49-2 (Deleted CAS) 170805-71-7 (Deleted CAS) 759445-89-1 (Deleted CAS) 787635-21-6 (Deleted CAS) 1150316-17-8 (Deleted CAS)
White Crystals or Crystalline Powder
1.432 g/cm3
Melting Point
300°C (dec.)
Boiling Point
212.9±23.0°C at 760 mmHg
Store at -20°C
Soluble in Aqueous Acid (Slightly), Water (Slightly), Aqueous Base (Slightly)
Alanine is an amino acid that can act as a skin-conditioning agent. It is usually used in combination with other amino acids.
InChI Key
Canonical SMILES
1.Metabolic engineering of microorganisms for L-alanine production
J Ind Microbiol Biotechnol. 2022 Apr 14;49(2):kuab057. doi: 10.1093/jimb/kuab057.
L-alanine is extensively used in chemical, food, and medicine industries. Industrial production of L-alanine has been mainly based on the enzymatic process using petroleum-based L-aspartic acid as the substrate. L-alanine production from renewable biomass using microbial fermentation process is an alternative route. Many microorganisms can naturally produce L-alanine using aminotransferase or L-alanine dehydrogenase. However, production of L-alanine using the native strains has been limited due to their low yields and productivities. In this review, metabolic engineering of microorganisms for L-alanine production was summarized. Among them, the Escherichia coli strains developed by Dr. Lonnie Ingram's group which can produce L-alanine with anaerobic fermentation process had several advantages, especially having high L-alanine yield, and it was the first one that realized commercialization. L-alanine is also the first amino acid that could be industrially produced by anaerobic fermentation.
2.[Alanine aminotransferase (ALT)]
Nihon Rinsho. 1995 May;53(5):1146-50.
Alanine aminotransferase (Alt, L-alanine:2-oxoglutalate aminotransferase) is a pyridoxal enzyme which catalyses the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate. The enzyme is widely distributed in various tissues from animals and even in some kind of plants. Isoenzymes of human ALT localize in the cytosol (c-ALT) and mitochondria (m-ALT) of tissues such as liver, kidney, skeletal and cardiac muscles. Amino acid sequence of c-ALT from rat and human liver has been wholly determined by Ishiguro et al. It is suggested that c-ALT is associated to the utilization of pyruvate in glycolysis and m-ALT is involved in the conversion of alanine to pyruvate for gluconeogenesis.
3.Biomedical applications of L-alanine produced by Pediococcus acidilactici BD16 (alaD+)
Appl Microbiol Biotechnol. 2022 Feb;106(4):1435-1446. doi: 10.1007/s00253-022-11766-9.
L-alanine possesses extensive physiological functionality and tremendous pharmacological significance, therefore could be considered as potential ingredient for food, pharmaceutical, and personal care products. However, therapeutic properties of L-alanine still need to be addressed in detail to further strengthen its utilization as a viable ingredient for developing natural therapeutics with minimum side effects. Thus, the present study was aimed to explore the anticipated therapeutic potential of L-alanine, produced microbially using a lactic acid bacterial strain Pediococcus acidilactici BD16 (alaD + ) expressing L-alanine dehydrogenase enzyme. The anticipated therapeutic potential of L-alanine was assessed in terms of anti-proliferative, anti-bacterial, and anti-urolithiatic properties. Anti-bacterial assays revealed that L-alanine successfully inhibited growth and in vitro proliferation of important human pathogens including Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, Streptococcus mutans, and Vibrio cholerae in a concentration-dependent manner. Current investigation has also revealed its significant anti-proliferative potential against human lung adenocarcinoma (A549; IC 50 7.32 μM) and mammary gland adenocarcinoma (MCF-7; IC 50 8.81 μM) cells. The anti-urolithiatic potential of L-alanine was augmented over three different phases, viz., nucleation inhibition, aggregation inhibition, and oxalate depletion. Further, an in vitro cell culture-based kidney stone dissolution model using HEK293-T cells was also established to further strengthen its anti-urolithiatic potential. This is probably the first in vitro cell culture-based model which experimentally validates the immense therapeutic efficacy of L-alanine in treating urolithiasis disease. KEY POINTS: • Assessment of therapeutic potential of L-alanine produced by LAB. • L-alanine exhibited significant anti-proliferative and anti-bacterial activities. • L-alanine as potential anti-urolithiatic agent.
Online Inquiry
Verification code
Inquiry Basket