L-Alanine methyl ester hydrochloride (BAT-003953)
* For research use only

L-Alanine methyl ester is a derivative of L-Alanine. L-Alanine is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes. L-Alanine is a non-essential amino acid for human development and is one of the 20 amino acids encoded by the genetic code.

Category
L-Amino Acids
Catalog number
BAT-003953
CAS number
2491-20-5
Molecular Formula
C4H9NO2·HCl
Molecular Weight
139.60
L-Alanine methyl ester hydrochloride
Synonyms
L-Ala-OMe HCl; L-Alaninemethylesterhydrochloride; L-Alanine Methyl Ester Hydrochloride; (S)-Methyl 2-aminopropanoate hydrochloride; H-Ala-OMe HCl; L-2-amino-propanoic acid methyl ester hydrochloride
Appearance
White powder
Purity
≥ 99% (HPLC)
Melting Point
100-115 °C
Boiling Point
101.5 °C at 760 mmHg
Storage
Store at 2-8 °C
1.Synthesis and activity of HCO-Met-Leu-Phe-OMe analogues containing beta-alanine or taurine at the central position.
Giordano C1, Lucente G, Nalli M, Pagani Zecchini G, Paglialunga Paradisi M, Varani K, Spisani S. Farmaco. 2003 Nov;58(11):1121-30.
New synthetic analogues of the chemotactic N-formyltripeptide HCO-Met-Leu-Phe-OMe have been synthesized. The reported new models, namely Boc-Met-beta-Ala-Phe-OMe (1), HCO-Met-beta-Ala-Phe-OMe (2), Boc-Met-Tau-Phe-OMe (3), HCO-Met-Tau-Phe-OMe (4) and HCl.Met-Tau-Phe-OMe (5), are characterized by the presence at the central position of a residue of beta-alanine or 2-aminoethanesulfonic acid (taurine) replacing the native L-leucine. Whereas tripeptides 1 and 2 have been found quite inactive as chemoattractants, all the three models containing the Tau residue exhibit a remarkable activity. Superoxide anion production and lysozyme release have been also evaluated and the biological results are discussed together with the conformational preferences of the examined models.
2.Galanin stimulates the N-methyl-D-aspartate receptor/nitric oxide/cyclic GMP pathway in vivo in the rat ventral hippocampus.
Consolo S1, Uboldi MC, Caltavuturo C, Bartfai T. Neuroscience. 1998 Aug;85(3):819-26.
We investigated whether the neuropeptide galanin affects the nitric oxide synthase/cyclic GMP pathway in rat hippocampus by measuring in vivo the extracellular cyclic GMP levels during microdialysis. Galanin (2.5 and 3.5 nmol; i.c.v.) dose-dependently raised the extracellular levels of cyclic GMP in the ventral but not the dorsal hippocampus. The effect of 3.5 nmol galanin was blocked by local application of tetrodotoxin and inhibited by the high-affinity galanin antagonist M40 (galanin-[1-12]-Pro3-[Ala-Leu]2-Ala amide). The non-competitive N-methyl-D-aspartate receptor antagonist dizocilpine maleate (30 microM infused into the ventral hippocampus or 0.2 mg/kg, i.p.) and the competitive one, 3-([R]-carboxypiperazin-4-yl)-propyl-phosphonic acid (50 microM infused), but not local perfusion of the AMPA antagonist 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2,3-dione (15 microM) abolished the galanin-evoked cyclic GMP response in the hippocampus.
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