L-Alanine tert-butyl ester hydrochloride
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L-Alanine tert-butyl ester hydrochloride

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L-Alanine tert-butyl ester is a protected form of L-Alanine. L-Alanine is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes. L-Alanine is a non-essential amino acid for human development and is one of the 20 amino acids encoded by the genetic code.

Category
L-Amino Acids
Catalog number
BAT-003955
CAS number
13404-22-3
Molecular Formula
C7H15NO2·HCl
Molecular Weight
181.70
L-Alanine tert-butyl ester hydrochloride
IUPAC Name
tert-butyl (2S)-2-aminopropanoate;hydrochloride
Synonyms
L-Ala-OtBu HCl; tert-Butyl(S)-2-Aminopropionate Hydrochloride; L-Alanine tert-Butyl Ester Hydrochloride; H-Ala-Otbu HCl; (S)-2-Aminopropionic acid tert-Butyl ester hydrochloride; tert-butyl(2S)-2-aminopropanoate hydrochloride
Appearance
White crystalline powder
Purity
97.5-102.5% (Assay by titration)
Melting Point
168-175 °C (dec.)
Boiling Point
206.8 °C at 760 mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C7H15NO2.ClH/c1-5(8)6(9)10-7(2,3)4;/h5H,8H2,1-4H3;1H/t5-;/m0./s1
InChI Key
WIQIWPPQGWGVHD-JEDNCBNOSA-N
Canonical SMILES
CC(C(=O)OC(C)(C)C)N.Cl

L-Alanine tert-butyl ester hydrochloride, a derivative of L-alanine, finds widespread utility in research and synthetic chemistry. Here, delve into the diverse applications of L-Alanine tert-butyl ester hydrochloride, presented with a high degree of perplexity and burstiness:

Peptide Synthesis: Central to peptide synthesis, L-Alanine tert-butyl ester hydrochloride serves as a pivotal building block in the intricate chemical construction of peptides. By safeguarding the amino acid functional groups during peptide elongation, it shields against undesired side reactions, ensuring the meticulous assembly of complex peptide sequences vital for diverse biological inquiries and drug development endeavors.

Pharmaceutical Development: A cornerstone in pharmaceutical synthesis, this compound plays a vital role in crafting pharmaceutical intermediates and active components. Inclusion of L-Alanine tert-butyl ester hydrochloride in drug synthesis pathways empowers chemists to enhance the pharmacokinetic attributes of novel therapeutic agents. This modification elevates the stability, solubility, and bioavailability of pharmaceutical compounds, fostering advancements in medicinal science.

Proteomics Research: Within the realm of proteomics, L-Alanine tert-butyl ester hydrochloride emerges as an indispensable tool for the labeling and modification of proteins, enabling in-depth investigations into their structure and function. Incorporation of this compound into proteins through chemical alteration facilitates diverse analytical techniques, like mass spectrometry. Such methodologies aid in unraveling protein interactions, post-translational modifications, and functional sites, shedding light on intricate biological processes.

Organic Synthesis: In the domain of organic chemistry, L-Alanine tert-butyl ester hydrochloride assumes a multifaceted role as a versatile reagent for synthesizing a myriad of intricate molecules. Harnessing steric hindrance and electronic effects, it exerts influence over reaction pathways. This establishes its significance as an invaluable instrument for generating natural products, fine chemicals, and cutting-edge materials, underscoring its pivotal place in organic synthesis endeavors.

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