L-Aspartic acid
Need Assistance?
  • US & Canada:
    +
  • UK: +

L-Aspartic acid

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

L-Aspartic Acid is a non-essential amino acid found in food sources and dietary supplements. L-Aspartic Acid is one of the 20 proteinogenic amino acids; the building blocks of proteins. Its conjugate base L-aspartate is an excitatory neurotransmitter in the central nervous system.

Category
L-Amino Acids
Catalog number
BAT-014297
CAS number
56-84-8
Molecular Formula
C4H7NO4
Molecular Weight
133.10
L-Aspartic acid
IUPAC Name
(2S)-2-aminobutanedioic acid
Synonyms
Aspartic acid, L-; (+)-L-Aspartic acid; (+)-Aspartic acid; (S)-2-Aminobutanedioic acid; (S)-Aminobutanedioic acid; (S)-Aspartic acid; L-(+)-Aspartic acid; L-Aminosuccinic acid; L-Asparagic acid; L-Asparaginic acid; Asparagic acid; Asparaginic acid; Aspartic acid; Butanedioic acid, amino-, (S)-; H-Asp-OH; NSC 3973; NSC 79553
Related CAS
6899-03-2 (Deleted CAS) 181119-33-5 (Deleted CAS) 2139279-07-3 (Deleted CAS) 617-45-8 (DL-isomer) 1783-96-6 (D-isomer)
Appearance
White Crystals or Crystalline Powder
Purity
>98%
Density
1.661 g/cm3
Melting Point
270-271°C
Boiling Point
264.1±30.0°C at 760 Torr
Storage
Store at RT
Solubility
Soluble in Water
InChI
InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChI Key
CKLJMWTZIZZHCS-REOHCLBHSA-N
Canonical SMILES
C(C(C(=O)O)N)C(=O)O

L-Aspartic acid, a non-essential amino acid, serves as a vital building block in protein biosynthesis. It is naturally found within the human body and can be obtained from dietary sources, primarily in protein-rich foods such as meat, fish, eggs, and dairy products. Structurally characterized by an additional carboxyl group, L-aspartic acid falls under the category of acidic amino acids. Functionally, it plays numerous roles in the body’s metabolic processes, contributing to energy production and nitrogen metabolism. Furthermore, L-Aspartic acid is a precursor to other amino acids, including asparagine and arginine, and participates actively in the urea cycle, which detoxifies ammonia, a byproduct of protein metabolism in the liver.

One crucial application of L-Aspartic acid is in the field of sports nutrition and supplementation. Athletes and bodybuilders often use it to enhance physical performance and support muscle growth. This amino acid is thought to boost stamina by increasing energy levels and reducing fatigue during strenuous exercise. Additionally, L-aspartic acid assists in the synthesis of other amino acids, which are crucial for muscle repair and growth after intense physical activities. By facilitating better energy metabolism, L-aspartic acid supplements are commonly included in pre-workout formulations to improve athletic performance and endurance.

In the pharmaceutical industry, L-Aspartic acid is utilized for its therapeutic benefits, particularly in the treatment of chronic fatigue syndrome and depression. Its role as a neurotransmitter underscores its efficacy in supporting mental health by facilitating communication between neurons. L-Aspartic acid has been shown to enhance the production of certain chemicals that are essential for mood regulation and cognitive function. Its capability to increase energy production at the cellular level makes it a valuable component in medications aimed at boosting energy levels and improving mental clarity and focus.

The food and beverage industry also capitalizes on the utility of L-Aspartic acid, notably in the manufacturing of low-calorie sweeteners like aspartame. Aspartame, a popular sugar substitute found in diet beverages and sugar-free products, is composed of two amino acids: L-Aspartic acid and phenylalanine. It provides sweetness without the high calories associated with regular sugar, making it an attractive option for consumers seeking weight management solutions. The use of L-Aspartic acid in aspartame production exemplifies its role in delivering taste satisfaction while maintaining dietary balance.

Furthermore, L-Aspartic acid finds application in biodegradable polymer production, contributing to the advancement of sustainable materials. By incorporating L-aspartic acid into polymer chains, researchers are able to develop environmentally friendly plastics that decompose more readily than conventional materials. This application is particularly significant in addressing the global challenge of plastic waste. Biodegradable polymers made from L-Aspartic acid not only reduce the environmental impact of plastic disposal but also offer innovative possibilities for packaging and agricultural uses, reflecting a commitment to sustainability and resource conservation.

1.Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses.
Zhao X;Sehgal M;Hou Z;Cheng J;Shu S;Wu S;Guo F;Le Marchand SJ;Lin H;Chang J;Guo JT J Virol. 2018 Feb 26;92(6). pii: e01535-17. doi: 10.1128/JVI.01535-17. Print 2018 Mar 15.
Interferon-induced transmembrane proteins (IFITMs) are restriction factors that inhibit the infectious entry of many enveloped RNA viruses. However, we demonstrated previously that human IFITM2 and IFITM3 are essential host factors facilitating the entry of human coronavirus (HCoV) OC43. In a continuing effort to decipher the molecular mechanism underlying IFITM differential modulation of HCoV entry, we investigated the roles of structural motifs important for IFITM protein posttranslational modifications, intracellular trafficking, and oligomerization in modulating the entry of five HCoVs. We found that three distinct mutations in IFITM1 or IFITM3 converted the host restriction factors to enhance entry driven by the spike proteins of severe acute respiratory syndrome coronavirus (SARS-CoV) and/or Middle East respiratory syndrome coronavirus (MERS-CoV). First, replacement of IFITM3 tyrosine 20 with either alanine or aspartic acid to mimic unphosphorylated or phosphorylated IFITM3 reduced its activity to inhibit the entry of HCoV-NL63 and -229E but enhanced the entry of SARS-CoV and MERS-CoV. Second, replacement of IFITM3 tyrosine 99 with either alanine or aspartic acid reduced its activity to inhibit the entry of HCoV-NL63 and SARS-CoV but promoted the entry of MERS-CoV.
2.Short exposure to low concentrations of alcohol during embryonic development has only subtle and strain- dependent effect on the levels of five amino acid neurotransmitters in zebrafish.
Mahabir S;Chatterjee D;Gerlai R Neurotoxicol Teratol. 2018 Jul - Aug;68:91-96. doi: 10.1016/j.ntt.2018.05.005. Epub 2018 Jun 7.
The zebrafish has been successfully employed to model and study the effects of embryonic alcohol exposure. Short exposure to low alcohol concentrations during embryonic development has been shown to significantly disrupt social behavior as well as the dopaminergic and serotoninergic systems in zebrafish. However, analysis of potential effects of embryonic alcohol exposure on other amino acid neurotransmitter systems has not been performed. Here we analyzed neurochemicals obtained from adult AB and TU strain zebrafish that were immersed in 0.00% (control), 0.25%, 0.50%, 0.75% or 1.00% alcohol solution (vol/vol%) at 24 h post-fertilization for 2 h. From whole brain extracts, we quantified glutamate, aspartate, glycine, taurine and GABA levels using high performance liquid chromatography (HPLC). We found embryonic alcohol exposure not to have any significant effect on the levels of glutamate, aspartate, glycine and GABA in both AB and TU zebrafish. AB zebrafish showed a significant elevation of taurine levels, but only in the highest alcohol dose group compared to control. These results, albeit mainly negative, together with prior findings suggest that behavioral abnormalities resulting from embryonic alcohol exposure described before for AB zebrafish may primarily be due to altered dopaminergic and serotoninergic mechanisms.
3.Anti-Diabetic Effects of
Moezi L;Arshadi SS;Motazedian T;Seradj SH;Dehghani F Iran J Pharm Res. 2018 Winter;17(1):353-364.
Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugar and abnormalities in insulin secretion and action. There are many anti-diabetic plants, which might supply useful sources for developing new medicines that can be used in treatment of diabetes mellitus. The primary objective of the present investigation is to evaluate the anti-diabetic properties of the aerial parts of ;Amygdalus lycioides; in streptozocin-induced diabetic rats. Sixty rats were divided into 6 groups: streptozocin-induced diabetic control, insulin-treated diabetic group, and four ;Amygdalus lycioides;-treated diabetic groups (125, 250, 500, and 1000 mg/kg/day). After 2 weeks of plant extract administration, the effects of extracts on blood glucose, body weight, BUN, creatinine, total cholesterol, LDL, HDL, triglyceride, total protein, Na, K, and plasma enzymes (aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase) were analyzed. The pancreas of rats was also stained for stereological studies. Phytochemical evaluation of this extract showed the presence of flavonoids and tannins compounds. Glucose serum levels and glucose tolerance test showed a decrease in treatment with ;Amygdalus lycioides; (1000 mg/kg).
Online Inquiry
Verification code
Inquiry Basket