Need Assistance?

US & Canada:
+
UK: +

Our Highlights

GMP Grade Efficient workshop for GMP production.
Optimal Prices Buying products on this site guarantees the best price!
Commercial Batches Independent GMP manufacturing suites that handle commercial batches
Prompt Delivery Warehouses in multiple cities to ensure timely delivery
Flexible Quantity Quantities available from milligrams to ton

L-Aspartic acid β-tert-butyl ester

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

L-Aspartic acid 4-tert-butyl ester is a protected form of L-Aspartic acid. L-Aspartic acid is a non-essential amino acid that is used to biosynthesize other amino acids within the human body. L-Aspartic acid also increases membrane conductance of mammalian neurons by voltage-dependent means, causing depolarization and nerve impulses that travel to key areas of the central nervous system.

Category

L-Amino Acids

Catalog number

BAT-004122

CAS number

3057-74-7

Molecular Formula

C8H15NO4

Molecular Weight

189.20

Specification
Reference Reading

IUPAC Name

(2S)-2-amino-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid

Synonyms

L-Aspartic acid β-tert-butyl ester; L-aspartic acid 4-tert-butyl ester; (2S)-2-amino-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid

Appearance

White powder

Purity

≥ 98% (Assay)

Density

1.162±0.06 g/cm3

Melting Point

220 °C (dec.)

Boiling Point

318.7±37.0 °C

Storage

Store at RT

InChI

InChI=1S/C8H15NO4/c1-8(2,3)13-6(10)4-5(9)7(11)12/h5H,4,9H2,1-3H3,(H,11,12)/t5-/m0/s1

InChI Key

MXWMFBYWXMXRPD-YFKPBYRVSA-N

Canonical SMILES

CC(C)(C)OC(=O)CC(C(=O)O)N

1.Synthesis of the C-terminal half of thymosin alpha 1 by the polymeric reagent method.

Mokotoff M, Patchornik A. Int J Pept Protein Res. 1983 Feb;21(2):145-54.

In this report we further show the utility and efficiency of polymer-bound 1-hydroxybenzotriazole (PHBT) as an almost ideal support for the polymeric reagent method of peptide synthesis. This was demonstrated by the synthesis of thymosin alpha 1 (15-28), in which two suitably blocked segments, Boc-Asp (OtBu)-Leu-Lys (2Cz)-Glu (OBzl)-Lys (2Cz)-Lys (2Cz)-OH (3) and Boc-Glu (OBzl)-Val-Val-Glu (OBzl)-Glu (OBzl)-Ala-Glu (OBzl)-Asn-OBzl (2), were prepared entirely by utilizing PHBT activation for each coupling step. After appropriate deblocking of 2, segments 2 and 3 were coupled by the DCC-HOBT method, followed by complete deblocking and ion-exchange chromatographic purification, affording the C-terminal half of thymosin alpha 1, H-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (1).