1. Asymptomatic Hypertrophic Cardiomyopathy: Diagnosis and Therapy
Virginia Luis Fuentes, Lois J Wilkie Vet Clin North Am Small Anim Pract. 2017 Sep;47(5):1041-1054. doi: 10.1016/j.cvsm.2017.05.002. Epub 2017 Jun 27.
Hypertrophic cardiomyopathy (HCM) affects 15% of cats, and prevalence increases with age. Although many cats with HCM have normal life expectancy, some cats die suddenly, or develop congestive heart failure or arterial thromboembolism (ATE). High-risk cats can be recognized by left atrial enlargement on echocardiography, which can be missed on physical examination, as a heart murmur is often absent. Alternatively, plasma biomarkers can be measured as an initial screening test; echocardiography is indicated in cats with plasma NT-probrain natriuretic peptide concentrations exceeding 100 pmol/L. High-risk cats should be treated with clopidogrel to reduce the risk of ATE.
2. 2,5-Di-methyl-phenyl quinoline-2-carboxy-l-ate
E Fazal, Manpreet Kaur, Jerry P Jasinski, S Nagarajan, B S Sudha Acta Crystallogr Sect E Struct Rep Online. 2014 Jan 15;70(Pt 2):o147. doi: 10.1107/S160053681400052X. eCollection 2014 Feb 1.
In the title compound, C18H15NO2, the dihedral angle between the mean planes of the quinoline ring system and the phenyl ring is 78.8 (1)°. The mean plane of the carboxyl-ate group is twisted from the mean planes of the quinoline ring system and phenyl ring by 1.5 (9) and 77.6 (4)°, respectively. In the crystal, mol-ecules are linked by weak C-H⋯O inter-actions, generating C(8) chains along [001]. Weak π-π stacking inter-actions are also observed [centroid-centroid separation = 3.6238 (12) Å].
3. Methyl 3'-benzyl-4'-(2,4-di-chloro-phen-yl)-1'-methyl-2-oxo-1-propyl-spiro-[indoline-3,2'-pyrrolidine]-3'-carboxy-l-ate
S Karthikeyan, K Sethusankar, Anthonisamy Devaraj, Manickam Bakthadoss Acta Crystallogr Sect E Struct Rep Online. 2014 Feb 12;70(Pt 3):o272. doi: 10.1107/S1600536814002621. eCollection 2014 Mar 1.
In the title compound, C30H30Cl2N2O3, the indole ring system is roughly planar, with a maximum deviation of 0.1039 (18) Å for the carbonyl C atom, and makes a dihedral angle of 86.61 (9)° with the mean plane of the pyrrolidine ring. This spiro pyrrolidine ring adopts an envelope conformation with the N atom at the flap position. The pyrrole ring of the indole ring system adopts a twisted conformation on the C-C(=O) bond. The mol-ecular structure is stabilized by an intra-molecular C-H⋯O hydrogen bond, which generates an S(6) ring motif, and a π-π inter-action [centroid-centroid distance = 3.6577 (12) Å] involving the 2,4-di-chloro-phenyl ring and the benzyl ring. In the crystal, mol-ecules are linked via C-H⋯O hydrogen bonds, forming C(9) chains running parallel to [10-1].
