L-b-Homothreonine hydrochloride
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L-b-Homothreonine hydrochloride

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Category
β−Amino acids
Catalog number
BAT-007588
CAS number
336182-14-0
Molecular Formula
C5H11NO3·HCl
Molecular Weight
169.61
L-b-Homothreonine hydrochloride
IUPAC Name
(3R,4R)-3-amino-4-hydroxypentanoic acid;hydrochloride
Synonyms
L-b-HomoThr-OH HCl; (3R,4R)-3-Amino-4-hydroxy-pentanoic acid hydrochloride; L-beta-Homothreonine hydrochloride; (3R,4R)-3-AMINO-4-HYDROXYPENTANOIC ACID HCl; H-L-Beta-homothr-oh HCl; L-beta-Homo-Thr-OH HCl; L beta Homo Thr OH HCl
Related CAS
192003-00-2 (free base)
Appearance
White powder or solids
Purity
≥ 95% (HPLC)
Storage
Store at 2-8 °C
InChI
InChI=1S/C5H11NO3.ClH/c1-3(7)4(6)2-5(8)9;/h3-4,7H,2,6H2,1H3,(H,8,9);1H/t3-,4-;/m1./s1
InChI Key
XFOXVGBKIZQZCB-VKKIDBQXSA-N
Canonical SMILES
CC(C(CC(=O)O)N)O.Cl
1. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
2. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
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