L-(-)-Carnitine - CAS 541-15-1

L-carnitine is a constituent striated muscle and liver, and also a cofactor involved in fatty acid metabolism for transporting fatty acids through the inner mitochondrial membrane. It also acts as an inhibitor of HDAC.
Nutritional supplement in health care products.

Category
Others
Catalog number
BAT-008091
CAS number
541-15-1
Molecular Formula
C7H15NO3
Molecular Weight
161.201
L-(-)-Carnitine
Ordering Information
Catalog Number Size Price Stock Quantity
BAT-008091 50 g $298 In stock
BAT-008091 100 g $498 In stock
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IUPAC Name
(3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate
Synonyms
Levocarnitine; Vitamin BT; (R)-Carnitine; Carnitor; ST-198; ST 198; ST198; (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate
Appearance
White to Off-White Solid
Purity
98%
Density
0.64 g/cm3
Melting Point
>180°C (dec.)
Boiling Point
287.5°C (rough estimate)
Solubility
Soluble in Methanol, Water
Application
Ingredient of health care products.
InChI
InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
InChI Key
PHIQHXFUZVPYII-ZCFIWIBFSA-N
Canonical SMILES
C[N+](C)(C)CC(CC(=O)[O-])O
1.Stabilization of the thermolabile variant S113L of carnitine palmitoyltransferase II.
Motlagh L1, Golbik R1, Sippl W1, Zierz S1. Neurol Genet. 2016 Feb 25;2(2):e53. doi: 10.1212/NXG.0000000000000053. eCollection 2016.
OBJECTIVE: Muscle carnitine palmitoyltransferase (CPT) II deficiency, the most common defect of lipid metabolism in muscle, is characterized by attacks of myoglobinuria without persistent muscle weakness.
2.The histopathologic effects of L-carnitine in Sodium Taurocholate Induced Severe Pancreatitis Model.
Karakahya M1, Gül M2, Işık S3, Aydın C4, Yiğitcan B5, Otan E6, Orug T7. Int Surg. 2016 Apr 27. [Epub ahead of print]
OBJECTIVE: To evaluate the histopathologic effects of L-carnitine (LC) in an experimental severe pancreatitis (SP) model induced with sodium taurocholate (STC).
3.C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man.
van de Beek MC1, Dijkstra IM1, van Lenthe H1, Ofman R1, Goldhaber-Pasillas D2, Schauer N2, Schackmann M1, Engelen-Lee JY3, Vaz FM1, Kulik W1, Wanders RJ1, Engelen M4,3, Kemp S1,4. PLoS One. 2016 Apr 28;11(4):e0154597. doi: 10.1371/journal.pone.0154597. eCollection 2016.
X-linked adrenoleukodystrophy (ALD), a progressive neurodegenerative disease, is caused by mutations in ABCD1 and characterized by very-long-chain fatty acids (VLCFA) accumulation. Virtually all males develop progressive myelopathy (AMN). A subset of patients, however, develops a fatal cerebral demyelinating disease (cerebral ALD). Hematopoietic stem cell transplantation is curative for cerebral ALD provided the procedure is performed in an early stage of the disease. Unfortunately, this narrow therapeutic window is often missed. Therefore, an increasing number of newborn screening programs are including ALD. To identify new biomarkers for ALD, we developed an Abcd1 knockout mouse with enhanced VLCFA synthesis either ubiquitous or restricted to oligodendrocytes. Biochemical analysis revealed VLCFA accumulation in different lipid classes and acylcarnitines. Both C26:0-lysoPC and C26:0-carnitine were highly elevated in brain, spinal cord, but also in bloodspots.
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