L-Cyclohexylalaninol hydrochloride
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L-Cyclohexylalaninol hydrochloride

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Category
Amino Alcohol
Catalog number
BAT-002638
CAS number
117160-99-3
Molecular Formula
C9H20ClNO
Molecular Weight
193.72
L-Cyclohexylalaninol hydrochloride
Synonyms
H-Cha-ol HCl; H-Phe(hexahydro)-ol HCl; (S)-2-Amino-3-cyclohexyl-1-propanol hydrochloride; (S)-(+)-2-Amino-3-cyclohexyl-1-propanol hydrochloride; (2S)-2-amino-3-cyclohexylpropan-1-ol hydrochloride
Purity
≥ 95%
Density
0.970 g/cm3
Melting Point
230 °C (dec.)(lit.)
Boiling Point
289.5 °C at 760 mmHg
InChI
InChI=1S/C9H19NO.ClH/c10-9(7-11)6-8-4-2-1-3-5-8;/h8-9,11H,1-7,10H2;1H/t9-;/m0./s1
InChI Key
BMHYDTXNZNVADC-FVGYRXGTSA-N
Canonical SMILES
C1CCC(CC1)CC(CO)N.Cl
1. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
2. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
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