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L-Cysteine Hydrochloride

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

L-cysteine hydrochloride is the salt form of L-cysteine, which acts as a histidine ammonia-lyase inhibitor.
Protein supplement in health care products.

Category

L-Amino Acids

Catalog number

BAT-008076

CAS number

52-89-1

Molecular Formula

C3H7NO2S.HCl

Molecular Weight

157.61

IUPAC Name

(2R)-2-amino-3-sulfanylpropanoic acid;hydrochloride

Synonyms

(r)-cysteinehydrochloride; (R)-Cysteine-hydrochloride; 3-Mercaptoalanine hydrochloride; Cystein chloride; Cysteine chlorhydrate; Cysteine chlorohydrate; Cysteine, hydrochloride, L-; cysteinechlorhydrate

Appearance

White crystalline powder

Purity

98%

Melting Point

140-142°C

Boiling Point

293.9°C at 760 mmHg

Storage

Store at RT

Solubility

Soluble in Aqueous Acid, DMSO, Water, Methanol

InChI

InChI=1S/C3H7NO2S.ClH/c4-2(1-7)3(5)6;/h2,7H,1,4H2,(H,5,6);1H/t2-;/m0./s1

InChI Key

IFQSXNOEEPCSLW-DKWTVANSSA-N

Canonical SMILES

C(C(C(=O)O)N)S.Cl

L-Cysteine Hydrochloride, an amino acid derivative widely utilized in diverse industrial and clinical settings, plays a pivotal role in various applications. Here are four key applications of L-Cysteine Hydrochloride:

Pharmaceutical Formulations: Serving as a key precursor in the synthesis of acetylcysteine, a potent mucolytic agent, L-Cysteine Hydrochloride finds its niche in respiratory therapeutics. Acetylcysteine, renowned for its ability to break down mucus and enhance airway clearance, offers significant benefits for individuals grappling with respiratory ailments like chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

Food and Beverage Industry: Delving into the realm of culinary craftsmanship, L-Cysteine Hydrochloride emerges as a vital ingredient, particularly in bakery products, where it excels as a dough conditioner. This multifaceted compound streamlines the baking process by reducing mixing time, enhancing dough elasticity, and thwarting the dreaded shrinkage of baked delights. Its inclusion guarantees a uniform quality and texture in culinary delights, such as bread and pastries.

Cosmetics and Personal Care: Unveiling its beauty prowess, L-Cysteine Hydrochloride graces the cosmetics industry with its fortifying properties, especially in hair care formulations. Recognized for its capacity to fortify and revitalize hair fibers, this compound aids in the synthesis of keratin, the backbone of healthy hair. Its incorporation in hair and skin care products is driven by its potential antioxidant prowess, promising nourishment and protection for your hair and skin.

Biochemical Research: In the realm of scientific inquiry, L-Cysteine Hydrochloride shines as a valuable ally in biochemical and molecular biology research endeavors. Its role as a reducing agent for disulfide bonds in proteins facilitates intricate studies on protein folding and structure. Moreover, it serves as a growth-promoting factor in specialized culture media formulations, fostering the proliferation of diverse microorganisms in laboratory settings and fueling groundbreaking research initiatives.

1. Derivatives of S-9-fluorenylmethyl-L-cysteine

M Bodanszky, M A Bednarek Int J Pept Protein Res. 1982 Nov;20(5):434-7. doi: 10.1111/j.1399-3011.1982.tb03064.x.

The 9-fluorenylmethyl (Fm) group was examined with respect to its potential for blocking the sulfhydryl function. The S-Fm group is resistant to acids and to catalytic hydrogenation but is cleaved by ammonia in methanol or by organic bases, such as a 20% solution of piperidine in dimethylformamide. Synthesis of N-tert.-butyloxycarbonyl-S-9-fluorenylmethyl-L-cysteine p-nitrophenyl ester and of cysteinyl peptides protected with the S-Fm group are described.

2. Far-infrared terahertz properties of L-cysteine and its hydrochloride monohydrate

Guanhua Ren, Siqi Zong, Zhongjie Zhu, Chao Cheng, Ligang Chen, Lu Zhou, Jianbing Zhang, Liyuan Liu, Jiaguang Han, Hongwei Zhao Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 15;225:117476. doi: 10.1016/j.saa.2019.117476. Epub 2019 Aug 19.

As the building blocks of proteins, amino acids serve vital metabolic functions in addition to protein synthesis and thus attract enormous interest. Here we reported the far-infrared optical properties of L-cysteine (Lcys) and its hydrochloride monohydrate (LCHM) characterized by terahertz time-domain spectroscopy. The Lcys and LCHM exhibit quite distinct characteristics in the terahertz region due to diverse collective vibrations of the molecules, which is further confirmed by the solid-state density functional theory (DFT) calculations. The presented studies indicate that the intermolecular hydrogen bonds play a critical role in the far-infrared terahertz response of Lcys and LCHM.

3. Chemical and Biological Properties of S-1-Propenyl-l-Cysteine in Aged Garlic Extract

Yukihioro Kodera, Mitsuyasu Ushijima, Hirotaka Amano, Jun-Ichiro Suzuki, Toshiaki Matsutomo Molecules. 2017 Mar 31;22(4):570. doi: 10.3390/molecules22040570.

S-1-Propenyl-l-cysteine (S1PC) is a stereoisomer of S-1-Propenyl-l-cysteine (SAC), an important sulfur-containing amino acid that plays a role for the beneficial pharmacological effects of aged garlic extract (AGE). The existence of S1PC in garlic preparations has been known since the 1960's. However, there was no report regarding the biological and/or pharmacological activity of S1PC until 2016. Recently, we performed a series of studies to examine the chemical, biological, pharmacological and pharmacokinetic properties of S1PC, and obtained some interesting results. S1PC existed only in trace amounts in raw garlic, but its concentration increased almost up to the level similar of SAC through aging process of AGE. S1PC showed immunomodulatory effects in vitro and in vivo, and reduced blood pressure in a hypertensive animal model. A pharmacokinetic study revealed that S1PC was readily absorbed after oral administration in rats and dogs with bioavailability of 88-100%. Additionally, S1PC had little inhibitory influence on human cytochrome P450 activities, even at a concentration of 1 mM. Based on these findings, S1PC was suggested to be another important, pharmacologically active and safe component of AGE similar to SAC. In this review, we highlight some results from recent studies on S1PC and discuss the potential medicinal value of S1PC.