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L-Glutamic acid-[1,2-13C2] is a labelled L-Glutamic acid. Glutamic acid is a non-essential amino acid that acts as an excitatory neurotransmitter in the CNS.
1.Multidrug resistance P-glycoprotein dampens SR-BI cholesteryl ester uptake from high density lipoproteins in human leukemia cells.
Spolitu S1, Uda S1, Deligia S1, Frau A1, Collu M2, Angius F1, Batetta B1. Am J Cancer Res. 2016 Feb 15;6(3):615-27. eCollection 2016.
Tumor cells are characterised by a high content of cholesterol esters (CEs), while tumor-bearing patients show low levels of high-density lipoproteins (HDLs). The origin and significance of high CE levels in cancer cell biology has not been completely clarified. Recent evidence that lymphoblastic cells selectively acquire exogenous CE from HDL via the scavenger receptor SR-BI has drawn attention to the additional membrane proteins involved in this pathway. P-glycopotein-MDR1 (P-gp) is a product of the MDR1 gene and confers resistance to antitumor drugs. Its possible role in plasma membrane cholesterol trafficking and CE metabolism has been suggested. In the present study this aspect was investigated in a lymphoblastic cell line selected for MDR1 resistance. CEM were made resistant by stepwise exposure to low (LR) and high (HR) doses of vincristine (VCR). P-gp activity ((3)H-vinblastine), CE content, CE and triglycerides (TG) synthesis ((14)C-oleate), neutral lipids and Dil-HDL uptake (fluorescence), SR-BI, ABCA1 and P-gp protein expression (western blotting) were determined.
![L-Glutamic acid-[1,2-13C2]](https://resource.bocsci.com/structure/l-glutamicacid-%5B1%2C2-13c2%5D.gif)
