L-β-Homoproline hydrochloride
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L-β-Homoproline hydrochloride

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L-β-Homoproline hydrochloride (CAS# 53912-85-9) is the hydrochloride salf from of (S)-2-Pyrrolidineacetic Acid (P997905), a starting material for GABA inhibitors.

Category
Cyclic Amino Acids
Catalog number
BAT-002569
CAS number
53912-85-9
Molecular Formula
C6H11NO2·HCl
Molecular Weight
165.66
L-β-Homoproline hydrochloride
IUPAC Name
2-[(2S)-pyrrolidin-2-yl]acetic acid;hydrochloride
Synonyms
L-β-HomoPro-OH HCl; (S)-2-(2-Pyrrolidinyl)acetic acid hydrochloride; (S)-Homoproline hydrochloride; H-Pro-OH HCl
Appearance
Pale-yellow to yellow-brown solid
Purity
≥ 98 %
Melting Point
208-210 ℃
Boiling Point
272.3 ℃ at 760 mmHg
Storage
Store at 2-8 ℃
InChI
InChI=1S/C6H11NO2.ClH/c8-6(9)4-5-2-1-3-7-5;/h5,7H,1-4H2,(H,8,9);1H/t5-;/m0./s1
InChI Key
VQDACVOAOJQTPR-JEDNCBNOSA-N
Canonical SMILES
C1CC(NC1)CC(=O)O.Cl
1. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
2. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
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