L-Lysine amide dihydrochloride
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L-Lysine amide dihydrochloride

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Category
L-Amino Acids
Catalog number
BAT-004000
CAS number
51127-08-3
Molecular Formula
C6H15N3O·2HCl
Molecular Weight
218.20
L-Lysine amide dihydrochloride
IUPAC Name
(2S)-2,6-diaminohexanamide;dihydrochloride
Synonyms
L-Lys-NH2 2HCl; 2,6-diaminohexanamide,dihydrochloride; L-Lysin-amid,Dihydrochloride
Appearance
White to off-white powder
Purity
≥ 95%
Melting Point
220-221 °C
Storage
Store at 2-8 °C
InChI
InChI=1S/C6H15N3O.2ClH/c7-4-2-1-3-5(8)6(9)10;;/h5H,1-4,7-8H2,(H2,9,10);2*1H/t5-;;/m0../s1
InChI Key
AIYVJLPYZQDCKV-XRIGFGBMSA-N
Canonical SMILES
C(CCN)CC(C(=O)N)N.Cl.Cl
1. Post-translationally modified conopeptides: Biological activities and pharmacological applications
Elsie C Jimenez Peptides. 2021 May;139:170525. doi: 10.1016/j.peptides.2021.170525. Epub 2021 Mar 5.
Conus venoms comprise a large variety of biologically active peptides (conopeptides or conotoxins) that are employed for prey capture and other biological functions. Throughout the course of evolution of the cone snails, they have developed an envenomation scheme that necessitates a potent mixture of peptides, most of which are highly post-translationally modified, that can cause rapid paralysis of their prey. The great diversity of these peptides defines the ecological interactions and evolutionary strategy of cone snails. Such scheme has led to some pharmacological applications for pain, epilepsy, and myocardial infarction, that could be further explored to ultimately find unique peptide-based therapies. This review focuses on ~ 60 representative post-translationally modified conopeptides that were isolated from Conus venoms. Various conopeptides reveal post-translational modifications of specific amino acids, such as hydroxylation of proline and lysine, gamma-carboxylation of glutamate, formation of N-terminal pyroglutamate, isomerization of l- to d-amino acid, bromination of tryptophan, O-glycosylation of threonine or serine, sulfation of tyrosine, and cysteinylation of cysteine, other than the more common disulfide crosslinking and C-terminal amidation. Many of the post-translationally modified peptides paved the way for the characterization, by alternative analytical methods, of other pharmacologically important peptides that are classified under 27 conopeptide families denoting pharmacological classes.
2. Optically active: microwave-assisted synthesis and characterization of L-lysine-derived poly (amide-imide)s
Ali Reza Alborzi, Saeed Zahmatkesh, Karim Zare, Javad Sadeghi Amino Acids. 2011 Jul;41(2):485-94. doi: 10.1007/s00726-010-0767-0. Epub 2010 Oct 14.
L-lysine hydrochloride was transformed to ethyl L-lysine dihydrochloride. This salt was reacted with trimellitic anhydride to yield the corresponding diacid (1). Microwave-assisted polycondensation results a series of novel Poly (amide-imide)s (PAI (a-i)). These polymers have inherent viscosities in the range of 0.23-0.66 dl g(-1), display optical activity from +8.02 to +15.11 (as there is no obvious regioselectivity between alpha and epsilon amino groups of the chiral diacid during the polymerization step then random orientation of diacid moieties along the polymer backbone can be predicted and the concept of "tacticity" cannot be addressed in this research), and are readily soluble in polar aprotic solvents. They start to decompose (T (10%)) above 362°C and display glass-transition temperatures at 119-153°C. All of the above polymers were fully characterized by UV, FT-IR and (1)H NMR spectroscopy, elemental analysis, thermogravimetric analyses, DSC, inherent viscosity measurement and specific rotation.
3. Small interfering RNA for cancer treatment: overcoming hurdles in delivery
Nitin Bharat Charbe, et al. Acta Pharm Sin B. 2020 Nov;10(11):2075-2109. doi: 10.1016/j.apsb.2020.10.005. Epub 2020 Oct 13.
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.
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