L-tert-Leucinol hydrochloride
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L-tert-Leucinol hydrochloride

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Category
Amino Alcohol
Catalog number
BAT-002641
CAS number
352545-44-9
Molecular Formula
C6H16ClNO
Molecular Weight
153.65
L-tert-Leucinol hydrochloride
IUPAC Name
(2S)-2-amino-3,3-dimethylbutan-1-ol;hydrochloride
Synonyms
H-Tle-ol HCl; H-(tBu)Gly-ol HCl; (S)-2-Amino-3,3-dimethyl-1-butanol hydrochloride; (S)-t-butyl-leucinol hydrochloride
InChI
InChI=1S/C6H15NO.ClH/c1-6(2,3)5(7)4-8;/h5,8H,4,7H2,1-3H3;1H/t5-;/m1./s1
InChI Key
BFBMCXSYQJNKSS-NUBCRITNSA-N
Canonical SMILES
CC(C)(C)C(CO)N.Cl
1. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
2. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
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