L-Tyrosine-[15N]
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L-Tyrosine-[15N]

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L-Tyrosine-[15N] is a labelled L-Tyrosine. Tyrosine is a non-essential amino acid synthesized from phenylalanine. It is the precursor of some neurotransmitters.

Category
Isotope Labelled Amino Acids
Catalog number
BAT-008166
CAS number
35424-81-8
Molecular Formula
C9H11[15N]O3
Molecular Weight
182.18
L-Tyrosine-[15N]
IUPAC Name
(2S)-2-(15N)azanyl-3-(4-hydroxyphenyl)propanoic acid
Synonyms
(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid-15N; 3-(4-Hydroxyphenyl)-L-alanine-15N; L-4-Hydroxyphenylalanine-15N; 15N Labeled L-tyrosine
Related CAS
60-18-4 (unlabelled)
Purity
98% by HPLC; 98% atom 15N
Melting Point
>300ºC (dec.)(lit.)
Storage
Store at-20 °C
InChI
InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1/i10+1
InChI Key
OUYCCCASQSFEME-YTRLMEAHSA-N
Canonical SMILES
C1=CC(=CC=C1CC(C(=O)O)N)O
2. Recent advances in biocatalytic derivatization of L-tyrosine
Xu Tan, Wei Song, Xiulai Chen, Liming Liu, Jing Wu Appl Microbiol Biotechnol. 2020 Dec;104(23):9907-9920. doi: 10.1007/s00253-020-10949-6. Epub 2020 Oct 17.
L-Tyrosine is an aromatic, polar, non-essential amino acid that contains a highly reactive α-amino, α-carboxyl, and phenolic hydroxyl group. Derivatization of these functional groups can produce chemicals, such as L-3,4-dihydroxyphenylalanine, tyramine, 4-hydroxyphenylpyruvic acid, and benzylisoquinoline alkaloids, which are widely employed in the pharmaceutical, food, and cosmetics industries. In this review, we summarize typical L-tyrosine derivatizations catalyzed by enzymatic biocatalysts, as well as the strategies and challenges associated with their production processes. Finally, we discuss future perspectives pertaining to the enzymatic production of L-tyrosine derivatives.Key points· Summary of recent advances in enzyme-catalyzed L-tyrosine derivatization.· Highlights of relevant strategies involved in L-tyrosine derivatives biosynthesis.· Future perspectives on industrial applications of L-tyrosine derivatization.
3. Heat Capacities of l-Histidine, l-Phenylalanine, l-Proline, l-Tryptophan and l-Tyrosine
Václav Pokorný, Vojtěch Štejfa, Jakub Havlín, Květoslav Růžička, Michal Fulem Molecules. 2021 Jul 15;26(14):4298. doi: 10.3390/molecules26144298.
In an effort to establish reliable thermodynamic data for proteinogenic amino acids, heat capacities for l-histidine (CAS RN: 71-00-1), l-phenylalanine (CAS RN: 63-91-2), l-proline (CAS RN: 147-85-3), l-tryptophan (CAS RN: 73-22-3), and l-tyrosine (CAS RN: 60-18-4) were measured over a wide temperature range. Prior to heat capacity measurements, thermogravimetric analysis was performed to determine the decomposition temperatures while X-ray powder diffraction (XRPD) and heat-flux differential scanning calorimetry (DSC) were used to identify the initial crystal structures and their possible transformations. Crystal heat capacities of all five amino acids were measured by Tian-Calvet calorimetry in the temperature interval from 262 to 358 K and by power compensation DSC in the temperature interval from 307 to 437 K. Experimental values determined in this work were then combined with the literature data obtained by adiabatic calorimetry. Low temperature heat capacities of l-histidine, for which no literature data were available, were determined in this work using the relaxation (heat pulse) calorimetry from 2 K. As a result, isobaric crystal heat capacities and standard thermodynamic functions up to 430 K for all five crystalline amino acids were developed.
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