LPYFD-NH2
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LPYFD-NH2

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LPYFD-NH2, is a neuroprotective peptide that binds to Amyloid-β. In vitro and in vivo it protects neurons against toxic effects of Aβ (1-42), which can be used in treating Alzheimer's Disease.

Category
Peptide Inhibitors
Catalog number
BAT-010290
CAS number
700361-48-4
Molecular Formula
C33H44N6O8
Molecular Weight
652.75
LPYFD-NH2
IUPAC Name
(3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acid
Synonyms
H-Leu-Pro-Tyr-Phe-Asp-NH2; (3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acid; ZINC98052568; AKOS024457970
Appearance
White lyophilised solid
Density
1.3±0.1 g/cm3
Melting Point
>185°C (dec.)
Boiling Point
1079.9±65.0°C at 760 mmHg
Sequence
H-Leu-Pro-Tyr-Phe-Asp-NH2
Storage
Store at -20°C
Solubility
Soluble to 2 mg/ml in 10% acetonitrile/water
InChI
1S/C33H44N6O8/c1-19(2)15-23(34)33(47)39-14-6-9-27(39)32(46)38-26(17-21-10-12-22(40)13-11-21)31(45)37-25(16-20-7-4-3-5-8-20)30(44)36-24(29(35)43)18-28(41)42/h3-5,7-8,10-13,19,23-27,40H,6,9,14-18,34H2,1-2H3,(H2,35,43)(H,36,44)(H,37,45)(H,38,46)(H,41,42)/t23-,24-,25-,26-,27-/m0/s1
InChI Key
IZXBZWOUOODINS-IRGGMKSGSA-N
Canonical SMILES
CC(C)CC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(=O)O)C(=O)N)N
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