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LPYFD-NH2

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

LPYFD-NH2, is a neuroprotective peptide that binds to Amyloid-β. In vitro and in vivo it protects neurons against toxic effects of Aβ (1-42), which can be used in treating Alzheimer's Disease.

Category

Peptide Inhibitors

Catalog number

BAT-010290

CAS number

700361-48-4

Molecular Formula

C33H44N6O8

Molecular Weight

652.75

Specification

IUPAC Name

(3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acid

Synonyms

H-Leu-Pro-Tyr-Phe-Asp-NH2; (3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acid; ZINC98052568; AKOS024457970

Appearance

White lyophilised solid

Density

1.3±0.1 g/cm3

Melting Point

>185°C (dec.)

Boiling Point

1079.9±65.0°C at 760 mmHg

Sequence

H-Leu-Pro-Tyr-Phe-Asp-NH2

Storage

Store at -20°C

Solubility

Soluble to 2 mg/ml in 10% acetonitrile/water

InChI

1S/C33H44N6O8/c1-19(2)15-23(34)33(47)39-14-6-9-27(39)32(46)38-26(17-21-10-12-22(40)13-11-21)31(45)37-25(16-20-7-4-3-5-8-20)30(44)36-24(29(35)43)18-28(41)42/h3-5,7-8,10-13,19,23-27,40H,6,9,14-18,34H2,1-2H3,(H2,35,43)(H,36,44)(H,37,45)(H,38,46)(H,41,42)/t23-,24-,25-,26-,27-/m0/s1

InChI Key

IZXBZWOUOODINS-IRGGMKSGSA-N

Canonical SMILES

CC(C)CC(C(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(=O)O)C(=O)N)N