Need Assistance?

US & Canada:
+
UK: +

FAQs

Resources

Our Highlights

GMP Grade Efficient workshop for GMP production.
Optimal Prices Buying products on this site guarantees the best price!
Commercial Batches Independent GMP manufacturing suites that handle commercial batches
Prompt Delivery Warehouses in multiple cities to ensure timely delivery
Flexible Quantity Quantities available from milligrams to ton

Application Area

Luteinizing Hormone-Releasing Hormone (LH-RH)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Luteinizing hormone releasing hormone (LH-RH) is a reproductive hormone.

Category

Others

Catalog number

BAT-010196

CAS number

86073-88-3

Molecular Formula

C60H73N15O13

Molecular Weight

1212.3

Luteinizing Hormone-Releasing Hormone (LH-RH)

Specification
Reference Reading

IUPAC Name

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Synonyms

Salmon-gnrh; Gnrh, salmon-; Salmon-LHRH; LHRH (salmon)

Purity

≥95%

Sequence

XHWSYGWLPG

Storage

Store at -20°C

Solubility

Soluble in DMSO

InChI

InChI=1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1

InChI Key

NMJREATYWWNIKX-XJIZABAQSA-N

Canonical SMILES

CC(C)CC(C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)CNC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8

1. Luteinizing hormone-releasing hormone antagonists

Gábor Mezo, Marilena Manea Expert Opin Ther Pat. 2009 Dec;19(12):1771-85. doi: 10.1517/13543770903410237.

Background: Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. Objective/method: Here we give an overview of the most relevant LH-RH antagonists and their therapeutic applications. Recently patented compounds as well as drug formulations and dosage are presented. Conclusion: LH-RH antagonists have found clinical applications in in vitro fertilization, benign prostatic hyperplasia, endometriosis and in the treatment of hormone-dependent tumors. Work in progress is focused on further development of both peptidic and orally active non-peptidic LH-RH antagonists.

3. [The radioimmunological assaying of the luteinizing hormone-releasing hormone (LH-RH) in human beings. A general review (author's transl)]

B Teuwissen, K Thomas J Gynecol Obstet Biol Reprod (Paris). 1981;10(4):315-33.

The authors attempted to work out a synthesis of the known factors about the specifications required for the levels of LH-RH and for finding this hormone in different human biological milieux. Searching for endogenous LH-RH in women, men and children has given very different results. The disparity between the levels that have been found, which are often at the very limits of detection by the methods used, can be explained by the type of specification of the level and by the effects of the biological milieu used and by the breakdown of endogenous LH-RH in the living organism. The conclusion is that the values that have been found up to now are not really reliable and of no great use in human clinical work.