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LZ1 peptide

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

LZ1 peptide is a synthetically derived antimicrobial peptide. It is known for its potent bactericidal effects, broad-spectrum antimicrobial activity, and lack of hemolytic activity and toxicity towards eukaryotic cells. It also exhibits anti-inflammatory properties by inhibiting the secretion of inflammatory factors such as tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-1β, which can help in managing inflammation caused by acne. LZ1 peptide is a potent antimicrobial agent used in cosmetics for its ability to combat acne-causing bacteria and reduce inflammation. It is known for its effectiveness in treating inflammatory acne, improving skin texture, and potentially reducing the appearance of acne scars. Additionally, LZ1 peptide contributes to skin health by providing antioxidant properties and combating free radicals, which can help prevent skin aging and soothe sun-induced damage.

Category

Functional Peptides

Catalog number

BAT-016718

CAS number

1423743-97-8

Molecular Formula

C113H167N33O15

Molecular Weight

2227.75

Specification

IUPAC Name

(2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-3-methylbutanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]hexanamide

Synonyms

LZ1 antimicrobial peptide; Antimicrobial peptide LZ1 peptide; LZ1; H-Val-Lys-Arg-Trp-Lys-Lys-Trp-Trp-Arg-Lys-Trp-Lys-Lys-Trp-Val-NH2; H-VKRWKKWWRKWKKWV-NH2; L-Valyl-L-lysyl-L-arginyl-L-tryptophyl-L-lysyl-L-lysyl-L-tryptophyl-L-tryptophyl-L-arginyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-tryptophyl-L-valinamide; Val-Lys-Arg-Trp-Lys-Lys-Trp-Trp-Arg-Lys-Trp-Lys-Lys-Trp-Val-NH2

Purity

≥95%

Density

1.421±0.14 g/cm3

Sequence

VKRWKKWWRKWKKWV-NH2

Storage

Store at -20 °C

InChI

InChI=1S/C113H167N33O15/c1-65(2)95(120)111(161)140-87(44-20-26-52-119)100(150)136-89(46-28-54-127-113(124)125)105(155)142-91(56-68-61-129-78-35-11-6-30-73(68)78)107(157)138-82(39-15-21-47-114)98(148)133-84(41-17-23-49-116)103(153)143-93(58-70-63-131-80-37-13-8-32-75(70)80)109(159)145-92(57-69-62-130-79-36-12-7-31-74(69)79)108(158)139-88(45-27-53-126-112(122)123)101(151)135-85(42-18-24-50-117)102(152)141-90(55-67-60-128-77-34-10-5-29-72(67)77)106(156)137-83(40-16-22-48-115)99(149)134-86(43-19-25-51-118)104(154)144-94(110(160)146-96(66(3)4)97(121)147)59-71-64-132-81-38-14-9-33-76(71)81/h5-14,29-38,60-66,82-96,128-132H,15-28,39-59,114-120H2,1-4H3,(H2,121,147)(H,133,148)(H,134,149)(H,135,151)(H,136,150)(H,137,156)(H,138,157)(H,139,158)(H,140,161)(H,141,152)(H,142,155)(H,143,153)(H,144,154)(H,145,159)(H,146,160)(H4,122,123,126)(H4,124,125,127)/t82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-/m0/s1

InChI Key

AEGLGCLRXLHQRT-YZCAGTBWSA-N

Canonical SMILES

CC(C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC7=CNC8=CC=CC=C87)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC9=CNC1=CC=CC=C19)C(=O)N[C@@H](C(C)C)C(=O)N)N