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Misgurin

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

A novel antimicrobial peptide, named misgurin, was isolated and characterized from the loach (mudfish), Misgurnus anguillicaudatus. Misgurin showed a strong antimicrobial activity in vitro against a broad spectrum of microorganisms without significant hemolytic activity and was about 6 times more potent than magainin 2.

Category

Functional Peptides

Catalog number

BAT-011932

Molecular Formula

C106H189N41O29

Molecular Weight

2501.88

Specification
Reference Reading

IUPAC Name

(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoic acid

Sequence

RQRVEELSKFSKKGAAARRRK

InChI

InChI=1S/C106H189N41O29/c1-55(2)50-73(143-94(168)70(36-39-79(152)153)140-93(167)71(37-40-80(154)155)141-100(174)81(56(3)4)147-95(169)68(34-23-49-127-106(121)122)137-92(166)69(35-38-77(112)150)133-85(159)61(111)26-19-45-123-102(113)114)96(170)145-75(53-148)98(172)139-64(29-13-17-43-109)91(165)144-74(51-60-24-9-8-10-25-60)97(171)146-76(54-149)99(173)138-63(28-12-16-42-108)87(161)134-62(27-11-15-41-107)86(160)128-52-78(151)129-57(5)82(156)130-58(6)83(157)131-59(7)84(158)132-65(31-20-46-124-103(115)116)88(162)135-66(32-21-47-125-104(117)118)89(163)136-67(33-22-48-126-105(119)120)90(164)142-72(101(175)176)30-14-18-44-110/h8-10,24-25,55-59,61-76,81,148-149H,11-23,26-54,107-111H2,1-7H3,(H2,112,150)(H,128,160)(H,129,151)(H,130,156)(H,131,157)(H,132,158)(H,133,159)(H,134,161)(H,135,162)(H,136,163)(H,137,166)(H,138,173)(H,139,172)(H,140,167)(H,141,174)(H,142,164)(H,143,168)(H,144,165)(H,145,170)(H,146,171)(H,147,169)(H,152,153)(H,154,155)(H,175,176)(H4,113,114,123)(H4,115,116,124)(H4,117,118,125)(H4,119,120,126)(H4,121,122,127)/t57-,58-,59-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,81-/m0/s1

InChI Key

MLIWTQXUIKBGEG-YQNYITMWSA-N

Canonical SMILES

CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCCNC(=N)N)N

3. SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Jitske Jansen, et al. Cell Stem Cell. 2022 Feb 3;29(2):217-231.e8. doi: 10.1016/j.stem.2021.12.010. Epub 2021 Dec 25.

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID.