N-α-(9-Fluorenylmethoxycarbonyl)-3-(1,2,3,4-tetrahydroquinolin-1-yl)-L-alanine
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N-α-(9-Fluorenylmethoxycarbonyl)-3-(1,2,3,4-tetrahydroquinolin-1-yl)-L-alanine

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Category
Fmoc-Amino Acids
Catalog number
BAT-001716
CAS number
2389078-97-9
Molecular Formula
C27H26N2O4
Molecular Weight
442.52
IUPAC Name
(2S)-3-(3,4-dihydro-2H-quinolin-1-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
Synonyms
Fmoc-Ala[3-(1-THQ)]-OH; Fmoc-Ala[3-(1,2,3,4-tetrahydroquinolin-1-yl)]-OH; N-alpha-(9-Fluorenylmethoxycarbonyl)-3-(1,2,3,4-tetrahydroquinolin-1-yl)-L-alanine
Storage
Store at -20 °C
InChI
InChI=1S/C27H26N2O4/c30-26(31)24(16-29-15-7-9-18-8-1-6-14-25(18)29)28-27(32)33-17-23-21-12-4-2-10-19(21)20-11-3-5-13-22(20)23/h1-6,8,10-14,23-24H,7,9,15-17H2,(H,28,32)(H,30,31)/t24-/m0/s1
InChI Key
UJOIDAZSTFNCQY-DEOSSOPVSA-N
Canonical SMILES
C1CC2=CC=CC=C2N(C1)CC(C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35

N-α-(9-Fluorenylmethoxycarbonyl)-3-(1,2,3,4-tetrahydroquinolin-1-yl)-L-alanine, a specialized reagent utilized in peptide synthesis, exhibits versatile applications within the realm of biosciences. Here are the key applications of this compound presented with high perplexity and burstiness:

Peptide Synthesis: Acting as a fundamental element in solid-phase peptide synthesis, this compound serves as a cornerstone for constructing specific peptide sequences for investigative purposes. Its protected amine group ensures precise and efficient integration into peptides, crucial for generating high-purity peptides essential in biochemical and pharmacological inquiries.

Drug Discovery: Within pharmaceutical research, this reagent plays a vital role in synthesizing peptide-based pharmaceutical candidates and therapeutic agents. By aiding in the production of modified peptides, researchers explore potential treatments for diverse diseases such as cancer, diabetes, and infectious diseases. This contributes to the discovery of innovative compounds with heightened target specificity and enhanced bioavailability.

Protein Structure-Function Studies: Researchers leverage this compound in synthesizing peptides that mimic pivotal protein regions, facilitating the study of protein structure and function. These peptides serve as valuable probes for investigating protein-protein interactions, enzymatic activities, and various biological processes. Understanding these intricate interactions is pivotal in unraveling molecular mechanisms and crafting precise, targeted therapies.

Bioconjugation Strategies: In the sphere of bioconjugation, this reagent emerges as a pivotal tool for linking peptides to other molecules like drugs, imaging agents, or nanoparticles. Through the incorporation of this specific amino acid derivative, scientists can engineer conjugates with tailored properties such as enhanced stability or targeted delivery. These bioconjugates find applications across diagnostics, therapeutics, and sophisticated targeted delivery systems.

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