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N-α-(9-Fluorenylmethoxycarbonyl)-3-(1-methylbenzimidazol-2-yl)-L-alanine

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category

Fmoc-Amino Acids

Catalog number

BAT-001717

CAS number

2382461-95-0

Molecular Formula

C26H23N3O4

Molecular Weight

441.49

Specification
Application

IUPAC Name

2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-methylbenzimidazol-2-yl)propanoic acid

Synonyms

Fmoc-Ala[2-Bim(1-Me)]-OH; Fmoc-Ala(1-Methylbenzimidazol-2-yl)-OH; N-alpha-(9-Fluorenylmethoxycarbonyl)-3-(1-methylbenzimidazol-2-yl)-L-alanine

Storage

Store at -20 °C

InChI

InChI=1S/C26H23N3O4/c1-29-23-13-7-6-12-21(23)27-24(29)14-22(25(30)31)28-26(32)33-15-20-18-10-4-2-8-16(18)17-9-3-5-11-19(17)20/h2-13,20,22H,14-15H2,1H3,(H,28,32)(H,30,31)

InChI Key

DDPQDQBLMXWVMP-UHFFFAOYSA-N

Canonical SMILES

CN1C2=CC=CC=C2N=C1CC(C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35

N-α-(9-Fluorenylmethoxycarbonyl)-3-(1-methylbenzimidazol-2-yl)-L-alanine, known as Fmoc-Bim(L), is a specialized amino acid derivative utilized in advanced biochemical and pharmaceutical research. Here are the key applications of Fmoc-Bim(L) presented with high perplexity and burstiness:

Peptide Synthesis: In the realm of solid-phase peptide synthesis, Fmoc-Bim(L) plays a crucial role in incorporating modified amino acids into peptide chains. This derivative enables the inclusion of unique chemical functionalities, expanding the diversity of synthetic peptides. Researchers leverage its capabilities to craft innovative peptides with specific properties tailored for therapeutic and diagnostic purposes.

Protein Engineering: Within the domain of protein engineering, Fmoc-Bim(L) emerges as a versatile tool for introducing precise modifications into proteins to enhance their stability, activity, or binding affinity. Its integration can lead to the creation of proteins with novel features that emulate post-translational modifications. This process is essential for engineering tailored enzymes, binding proteins, and therapeutic proteins with enhanced functionalities.

Bioconjugation: Fmoc-Bim(L) proves invaluable in bioconjugation methodologies, where it serves to attach biomolecules like fluorophores or drugs to peptides or proteins. This facilitates the development of conjugates for applications in imaging, targeting, or drug delivery systems. The unique chemical properties of Fmoc-Bim(L) streamline efficient and selective conjugation reactions, enabling precise control over the conjugation process.

Structural Biology: Within the realm of structural biology, Fmoc-Bim(L) finds application in modifying peptides and proteins for crystallization and structural determination. Its introduction aids in stabilizing specific conformations, thereby easing X-ray crystallography or NMR studies. This contribution is instrumental in unraveling the three-dimensional structures of biomolecules, essential for deciphering their intricate functions and interactions.