N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-benzothienyl)-L-β-homoalanine
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N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-benzothienyl)-L-β-homoalanine

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Category
Fmoc-Amino Acids
Catalog number
BAT-004696
CAS number
270063-46-2
Molecular Formula
C27H23NO4S
Molecular Weight
457.54
N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-benzothienyl)-L-β-homoalanine
IUPAC Name
(3S)-4-(1-benzothiophen-3-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid
Synonyms
Fmoc-Ala(3-Bzt)-(C#CH2)OH; (S)-3-[(9-Fluorenylmethoxycarbonyl)amino]-4-(3-benzothienyl)butanoic acid
Appearance
White powder
Purity
≥ 98%
Density
1.331±0.06 g/cm3(Predicted)
Boiling Point
702.4±60.0 °C(Predicted)
Storage
Store at 2-8 °C
InChI
InChI=1S/C27H23NO4S/c29-26(30)14-18(13-17-16-33-25-12-6-5-7-19(17)25)28-27(31)32-15-24-22-10-3-1-8-20(22)21-9-2-4-11-23(21)24/h1-12,16,18,24H,13-15H2,(H,28,31)(H,29,30)/t18-/m0/s1
InChI Key
AOUNLYYDVNQRKT-SFHVURJKSA-N
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CSC5=CC=CC=C54)CC(=O)O

N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-benzothienyl)-L-β-homoalanine, a synthetic amino acid derivative, plays a pivotal role in advanced biochemical research and peptide synthesis. Here are the key applications presented with high perplexity and burstiness:

Peptide Synthesis: The versatile N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-benzothienyl)-L-β-homoalanine finds widespread utility in peptide synthesis, empowering researchers to craft sequences with intricate modifications. Its Fmoc-protected structure enables targeted deprotection during solid-phase peptide synthesis, streamlining the creation of intricate peptides with potential therapeutic and diagnostic implications.

Protein Engineering: Delving into the realm of protein engineering, this synthetic amino acid derivative can be strategically integrated into proteins to investigate structure-function relationships and engineer proteins with novel attributes. By strategically introducing this compound at specific locations, researchers can probe protein stability, folding dynamics, and interactions, laying the groundwork for the design of proteins with heightened functionalities and therapeutic potentialities.

Drug Discovery: Serving as a valuable asset in drug discovery endeavors, N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-benzothienyl)-L-β-homoalanine aids in screening and developing pharmaceutical agents. By integrating this amino acid derivative into peptide libraries, researchers can pinpoint binding motifs and active sites pertinent to potential drug targets, expediting the identification of lead compounds and the refinement of drug candidates.

Bioconjugation: The distinctive chemical composition of this compound lends itself to bioconjugation strategies, enabling its attachment to various biomolecules to augment their properties. Whether utilized for labeling peptides or proteins with fluorescent tags for enhanced imaging capabilities and tracking functionalities in biological investigations, this compound plays a critical role in diagnostic assay applications and the development of sophisticated therapeutic delivery systems.

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