N-α-(9-Fluorenylmethoxycarbonyl)-N-ω1,N-δ-di(carbobenzoxy)-L-arginine
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N-α-(9-Fluorenylmethoxycarbonyl)-N-ω1,N-δ-di(carbobenzoxy)-L-arginine

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Category
Fmoc-Amino Acids
Catalog number
BAT-001779
CAS number
1094617-45-4
Molecular Formula
C37H36N4O8
Molecular Weight
664.72
IUPAC Name
2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[phenylmethoxycarbonyl-(N-phenylmethoxycarbonylcarbamimidoyl)amino]pentanoic acid
Synonyms
Fmoc-Arg(Z)2-OH; (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[phenylmethoxycarbonyl-[(E)-N'-phenylmethoxycarbonylcarbamimidoyl]amino]pentanoic acid
Storage
Store at -20 °C
InChI
InChI=1S/C37H36N4O8/c38-34(40-36(45)47-22-25-12-3-1-4-13-25)41(37(46)49-23-26-14-5-2-6-15-26)21-11-20-32(33(42)43)39-35(44)48-24-31-29-18-9-7-16-27(29)28-17-8-10-19-30(28)31/h1-10,12-19,31-32H,11,20-24H2,(H,39,44)(H,42,43)(H2,38,40,45)
InChI Key
PLFMYBVQTIUHOB-UHFFFAOYSA-N
Canonical SMILES
C1=CC=C(C=C1)COC(=O)NC(=N)N(CCCC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)OCC5=CC=CC=C5

N-α-(9-Fluorenylmethoxycarbonyl)-N-ω1,N-δ-di(carbobenzoxy)-L-arginine, a renowned protected arginine derivative, holds a pivotal role in peptide synthesis and various biochemical applications. Here are the key applications:

Peptide Synthesis: Acting as a fundamental component in solid-phase peptide synthesis, this protected arginine derivative features protective groups that shield against unwanted side reactions, ensuring the precise integration of the arginine residue into the peptide chain. This meticulous process is essential for the accurate construction of complex peptides and proteins, critical for cutting-edge research and therapeutic advancements.

Drug Development: Positioned at the forefront of pharmaceutical innovation, N-α-(9-Fluorenylmethoxycarbonyl)-N-ω1,N-δ-di(carbobenzoxy)-L-arginine plays a vital role in the creation of peptide-based drugs. Through the gentle removal of protective groups, the peptide’s integrity is maintained, facilitating the development of drugs targeting specific disease-related receptors or enzymes. This sophisticated approach enables the synthesis of personalized peptide drugs designed to combat intricate disease processes, ushering in a new era of drug discovery and advancement.

Biochemical Research: Empowering researchers in unraveling protein-protein interactions and signal transduction pathways, this compound proves to be invaluable. By incorporating the protected arginine into tailor-made peptides, scientists can decipher the functions and stability of specific arginine residues within proteins, shedding light on complex cellular mechanisms crucial for designing targeted therapeutic interventions. These insights offer great promise for biomedical progress.

Antibody Production: Harnessing custom peptides synthesized with protected arginine derivatives, scientists can create highly specific antibodies customized to recognize and bind to particular protein epitopes. These antibodies play a crucial role in various applications, including diagnostic assays and therapeutic antibody development, enhancing the precision and effectiveness of antibody-based techniques in both research and clinical settings. This revolutionizes the landscape of antibody production and utilization, showcasing the potential for enhanced antibody-based approaches.

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