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N-α-(9-Fluorenylmethoxycarbonyl)-β-(t-butyl)-L-alanine

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Fmoc-t-butyl-L-alanine is used in the synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. It is also an intermediate used to prepare oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.

Category

Fmoc-Amino Acids

Catalog number

BAT-005507

CAS number

139551-74-9

Molecular Formula

C22H25NO4

Molecular Weight

367.44

N-α-(9-Fluorenylmethoxycarbonyl)-β-(t-butyl)-L-alanine

Specification

IUPAC Name

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4,4-dimethylpentanoic acid

Synonyms

Fmoc-Ala(tBu)-OH; Fmoc-Leu(Me)-OH; N-α-(9-Fluorenylmethoxycarbonyl)-γ-methyl-L-leucine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-dimethylpentanoic acid; Fmoc-neopentylglycine; Fmoc-β-tBu-L-Ala-OH

Appearance

White to off-white solid

Purity

≥ 99.5% (Chiral HPLC)

Density

1.189±0.060 g/cm3

Storage

Store at 2-8 °C

InChI

InChI=1S/C22H25NO4/c1-22(2,3)12-19(20(24)25)23-21(26)27-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1

InChI Key

RPLVCXKSSXJFDS-IBGZPJMESA-N

Canonical SMILES

CC(C)(C)CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13