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N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-DL-3-aminoisobutyric acid

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category

Fmoc-Amino Acids

Catalog number

BAT-005371

CAS number

186320-19-4

Molecular Formula

C19H19NO4

Molecular Weight

325.37

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-DL-3-aminoisobutyric acid

Specification
Reference Reading

IUPAC Name

3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methylpropanoic acid

Synonyms

Fmoc-DL-Aib(3)-OH; Fmoc-DL-β-Aib-OH; N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-DL-3-amino-2-methylpropanoic acid

Purity

≥ 95%

Density

1.255 g/cm3

Boiling Point

555.3 °C at 760 mmHg

InChI

InChI=1S/C19H19NO4/c1-12(18(21)22)10-20-19(23)24-11-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,12,17H,10-11H2,1H3,(H,20,23)(H,21,22)

InChI Key

BMUDOYSTGJHGNI-UHFFFAOYSA-N

Canonical SMILES

CC(CNC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)C(=O)O

1.In-vivo imaging of blood-brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid.

Okada M1, Kikuchi T, Okamura T, Ikoma Y, Tsuji AB, Wakizaka H, Kamakura T, Aoki I, Zhang MR, Kato K. Nucl Med Commun. 2015 Dec;36(12):1239-48. doi: 10.1097/MNM.0000000000000385.

OBJECTIVE: The blood-brain barrier (BBB) limits the entry of some therapeutics into the brain, resulting in reduced efficacy. BBB-opening techniques have been developed to enhance the entry into the brain. However, a noninvasive, highly sensitive and quantitative method for evaluating the changes in BBB permeability induced by such techniques is needed to optimize treatment protocols. We evaluated 2-amino-[3-C]isobutyric acid ([3-C]AIB) as a PET probe to quantify BBB permeability in model rats.