N-Acetyl-D-prolinamide
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N-Acetyl-D-prolinamide

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Category
Cyclic Amino Acids
Catalog number
BAT-005896
CAS number
136051-77-9
Molecular Formula
C7H12N2O2
Molecular Weight
156.18
N-Acetyl-D-prolinamide
IUPAC Name
(2R)-1-acetylpyrrolidine-2-carboxamide
Synonyms
Ac-D-Pro-NH2; (R)-1-Acetylpyrrolidine-2-carboxamide
Purity
95%
Density
1.206±0.06 g/cm3
Boiling Point
411.9±34.0 °C
InChI
InChI=1S/C7H12N2O2/c1-5(10)9-4-2-3-6(9)7(8)11/h6H,2-4H2,1H3,(H2,8,11)/t6-/m1/s1
InChI Key
CXURPNUIYCJENH-ZCFIWIBFSA-N
Canonical SMILES
CC(=O)N1CCCC1C(=O)N
2. Probing the γ-turn in a short proline dipeptide chain
Carlos Cabezas, Marcelino Varela, José L Alonso Chemphyschem. 2013 Aug 5;14(11):2539-43. doi: 10.1002/cphc.201300250. Epub 2013 May 6.
The small peptide derived from proline, N-acetyl-prolinamide (Ac-Pro-NH2), has been investigated using a combination of Fourier transform microwave spectroscopy with laser ablation. Spectral signatures belonging to only one conformer have been detected in the supersonic expansion. Rotational constants and nuclear quadrupole coupling constants of the two (14)N nuclei have been used in the characterization of a γ-turn structure in the gas phase, which is stabilized by a CO···HN intramolecular hydrogen bond closing a seven-membered ring. A methyl group internal rotation barrier of 354 cm(-1) has been determined from the analysis of the A-E splittings.
3. Conformations of N-acetyl-L-prolinamide by two-dimensional infrared spectroscopy
Soohwan Sul, Denis Karaiskaj, Ying Jiang, Nien-Hui Ge J Phys Chem B. 2006 Oct 12;110(40):19891-905. doi: 10.1021/jp062039h.
Femtosecond two-dimensional infrared (2D IR) spectroscopy has been applied to study the conformations of a model dipeptide, N-acetyl-L-prolinamide (AcProNH2) in deuterated chloroform (CDCl3). Spectral features in the amide-I and -II regions are obtained by rephasing (R), nonrephasing (NR), and reverse photon echo (RPE) pulse sequences with two polarization conditions. The 2D spectra obtained by the RPE and NR sequences with (0, 0, 0, 0) polarization reveal new spectral features associated with the multiple conformers of AcProNH2 that are difficult to discern using R sequence and linear-IR spectroscopy. The high resolving power of the RPE sequence comes from destructive interference between the positive and negative peaks of nearby vibrators, similar to the NR sequence. The RPE response functions that are useful for 2D spectral simulations are evaluated, including the effects of vibrational frequency correlations. The 2D spectra obtained with (45, -45, 90, 0) polarization exhibit clear cross-peak patterns in the off-diagonal region for the R and RPE sequences but in the diagonal region for the NR sequence. These patterns, free from strong diagonal contributions, are crucial for structure determination. DFT calculations, normal-mode analysis, Hessian matrix reconstruction, and vibrational exciton Hamiltonian diagonalization yield molecular parameters needed for quantitative simulations of 2D spectra: angles between transition dipoles, coupling constants, and off-diagonal anharmonicities of the amide-I and -II modes are obtained for solvated trans-C7 and cis structures and for gas-phase trans conformers in the region of phi = -120 degrees to 0 degrees and psi = -100 degrees to 180 degrees in the Ramachandran space. Systematic simulations based on a 4:1 population ratio of the solvated trans-C7 and cis structures reproduce well the 2D spectral features obtained at both polarization conditions. However, better agreement between the experimental and simulated cross-peak patterns can be reached if the dihedral angles of the major trans conformer are close to (phi, psi) = (-80 degrees , 100 degrees ). Our results suggest that the major conformer of AcProNH2 in CDCl3 deviates from the gas-phase global minimum, the trans-C7 form, to an extended intermediate between the C7 and polyproline-II structure. These results are discussed in relationship with earlier findings obtained by NMR, transient IR studies, and MD simulations.
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