Nα-Acetyl-L-arginine methyl ester hydrochloride
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Nα-Acetyl-L-arginine methyl ester hydrochloride

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A substrate for pancreatic and intestinal kallikreins from different species. It is also hydrolyzed by trypsin.

Category
L-Amino Acids
Catalog number
BAT-004082
CAS number
1784-05-0
Molecular Formula
C9H18N4O3·HCl
Molecular Weight
266.77
Nα-Acetyl-L-arginine methyl ester hydrochloride
IUPAC Name
methyl (2S)-2-acetamido-5-(diaminomethylideneamino)pentanoate;hydrochloride
Synonyms
Ac-L-Arg-OMe HCl; N-Acetyl-L-arginine Methyl Ester Hydrochloride; AC-ARG-OME HCl
Appearance
White powder
Purity
≥ 99% (TLC)
Storage
Store at 2-8 °C
InChI
InChI=1S/C9H18N4O3.ClH/c1-6(14)13-7(8(15)16-2)4-3-5-12-9(10)11;/h7H,3-5H2,1-2H3,(H,13,14)(H4,10,11,12);1H/t7-;/m0./s1
InChI Key
FIUSXBMWQFBXLZ-FJXQXJEOSA-N
Canonical SMILES
CC(=O)NC(CCCN=C(N)N)C(=O)OC.Cl

Here are the key applications of Nα-Acetyl-L-arginine methyl ester hydrochloride presented with high perplexity and burstiness: Enzyme Inhibition Studies: Delving into enzyme dynamics, researchers utilize Nα-Acetyl-L-arginine methyl ester hydrochloride to probe the inhibition mechanisms of arginase, a pivotal enzyme in the urea cycle. By assuming roles as a substrate analogue or inhibitor, scientists dissect the enzyme’s intricate kinetics and craft potential therapeutic inhibitors. This application resonates notably in conditions like hyperargininemia and cardiovascular disorders, shedding light on vital biochemical pathways.

Pharmacological Research: A cornerstone in pharmaceutical exploration, this compound acts as a versatile tool for unraveling the biological activities of modified arginine derivatives. Researchers leverage it to evaluate the therapeutic potentials of arginine-related compounds in scenarios such as nitric oxide deficiency and immune dysregulation. Unraveling these interactions paves the way for designing novel drugs with heightened efficacy and enhanced safety profiles, pushing the boundaries of pharmacological innovation.

Cell Culture Studies: In the realm of cell biology, Nα-Acetyl-L-arginine methyl ester hydrochloride emerges as a significant supplement in cell culture media, offering insights into its impacts on cellular growth and metabolism. Particularly valuable for investigations into arginine metabolism and transport mechanisms across diverse cell types, these studies provide intricate glimpses into cellular dynamics and the roles of arginine derivatives in fostering cellular well-being and combating disease states.

Nutritional Biochemistry: Originating from an indispensable amino acid, this compound finds utility in unraveling the intricacies of amino acid supplementation and nutritional biology. Researchers meticulously explore its ramifications on protein synthesis, muscle metabolism, and overall nutritional well-being. This knowledge forms the bedrock for developing targeted nutritional therapies and supplements tailored to diverse health conditions, heralding a new era of personalized nutrition and wellness.

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