3-Azido-D-alanine hydrochloride
Need Assistance?
  • US & Canada:
    +
  • UK: +

3-Azido-D-alanine hydrochloride

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

3-Azido-D-alanine hydrochloride can be used in the research of click chemistry labeling.

Category
Azido Amino Acids
Catalog number
BAT-007746
CAS number
1379690-01-3
Molecular Formula
C3H7ClN4O2
Molecular Weight
166.57
IUPAC Name
(2R)-2-amino-3-azidopropanoic acid;hydrochloride
Synonyms
3-Azido-D-alanine HCl; beta-Azido-D-2,3-diaminopropionic acid hydrochloride; H-D-DAP(N3)-OH HCl
Related CAS
105928-88-9 (free base)
Purity
> 98%
Storage
Store at 2-8 °C
InChI
InChI=1S/C3H6N4O2.ClH/c4-2(3(8)9)1-6-7-5;/h2H,1,4H2,(H,8,9);1H/t2-;/m1./s1
InChI Key
MQDWRZHPCDDSJZ-HSHFZTNMSA-N
Canonical SMILES
C(C(C(=O)O)N)N=[N+]=[N-].Cl
1. Synthesis, analgesic and anti-inflammatory activities evaluation of some bi-, tri- and tetracyclic condensed pyrimidines
Kamilia M Amin, Mona M Hanna, Hanan E Abo-Youssef, Riham F George Eur J Med Chem. 2009 Nov;44(11):4572-84. doi: 10.1016/j.ejmech.2009.06.028. Epub 2009 Jul 1.
Novel series of bicyclic pyrrolo[1,2-c]pyrimidines 3a-g, 5, 6a, b, and 7a, b, tricyclic pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines 8a-c, 9a-g, 13a-c, 17, 18a, b, 19, 20a,b and 21 and tetracyclic condensed pyrimidines 14, 22 and 23 were synthesized through different chemical reactions. Structures of all synthesized pyrimidine derivatives were supported by spectral and elemental analyses. Analgesic activity evaluation was carried out using acetic acid-induced writhing assay, and all compounds exerted comparable activity to indomethacin. The anti-inflammatory activity evaluation was performed using carrageenan-induced paw edema in rats, the potency of the bicyclic derivatives 3a-f and 7b revealed comparable activity to indomethacin without gastric ulceration. The tricyclic derivatives 13a and 20a exerted good activity, however, they induced gastric ulcers while 13b and 13c showed moderate activity without ulceration. In case of tetracyclic derivatives, compound 14 exhibited the highest potency and safety profile.
2. One pot synthesis of pyrimidine and bispyrimidine derivatives and their evaluation for anti-inflammatory and analgesic activities
Sham M Sondhi, Shubhi Jain, Monica Dinodia, Rakesh Shukla, Ram Raghubir Bioorg Med Chem. 2007 May 15;15(10):3334-44. doi: 10.1016/j.bmc.2007.03.028. Epub 2007 Mar 13.
A number of pyrimidine derivatives (1-10) have been synthesized by condensation of 4-isothiocyanato-4-methylpentan-2-one with furfurylamine, histamine, 1-(3-aminopropyl)imidazole, 1-(3-aminopropyl)-2-pyrrolidinone, 2-aminobenzonitrile and 3-isothiocyanatobutanal with 1-(3-aminopropyl)-2-pyrrolidinone and 2-hydrazinopyridine under different reaction conditions. Various bispyrimidine derivatives (11-15) were obtained by condensation of 4-isothiocyanato-4-methylpentan-2-one with 2,4,8,10-tetraoxaspiro[5,5]undecane3,9-dipropamine (11'), 1,4-bis(3-aminopropyl)piperazine (13'), 3,5-diamino 1,2,4-triazole (15') and 3-isothiocyanatobutanal with 2,4,8,10-tetraoxaspiro[5,5]undecane 3,9-dipropamine, 1,4-bis(3-aminopropyl)piperazine. All these compounds were characterized by correct FT-IR, (1)H NMR, MS and elemental analysis. These compounds were screened for anti-inflammatory and analgesic activities. Anti-inflammatory activity of 3 is comparable while analgesic activity was found to be better than that of standard drug.
3. Synthesis, anti-inflammatory and analgesic activity evaluation of some amidine and hydrazone derivatives
Sham M Sondhi, Monica Dinodia, Ashok Kumar Bioorg Med Chem. 2006 Jul 1;14(13):4657-63. doi: 10.1016/j.bmc.2006.02.014. Epub 2006 Feb 28.
A number of amidine derivatives (3a-i) were synthesized by condensation of cyanopyridine and cyanopyrazine with sulfonylhydrazides in the presence of sodium methoxide. 2-Acetylpyridine and 4-acetylpyridine were condensed with sulfonylhydrazides by microwave irradiation in solid phase to give corresponding hydrazones (5a-d). Indole-3-carboxaldehyde was condensed with sulfonylhydrazides by refluxing in acetic acid to give corresponding condensation product (5e and f). All the compounds, that is, 3a-i and 5a-f were purified by crystallization or by column chromatography. Structures of all the synthesized compounds are supported by correct IR, (1)H NMR, mass spectral and analytical data. Anti-inflammatory activity evaluation was carried out using carrageenin-induced paw oedema assay and compounds 3e,f and 5e exhibited good anti-inflammatory activity, that is 52%, 37% and 38% at 50 mg/kg po, respectively. Analgesic activity evaluation was carried out using acetic acid writhing assay and compounds 3a,c,e and 5f showed good analgesic activity, that is, 50%, 50%, 50% and 60% at 50 mg/kg po, respectively.
Online Inquiry
Verification code
Inquiry Basket