Nα-Benzoyl-L-arginine methyl ester carbonate
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Nα-Benzoyl-L-arginine methyl ester carbonate

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A substrate for trypsin and kallikreins.

Category
L-Amino Acids
Catalog number
BAT-004100
CAS number
84332-93-4
Molecular Formula
C14H20N4O3·H2CO3
Molecular Weight
354.40
Nα-Benzoyl-L-arginine methyl ester carbonate
IUPAC Name
carbonic acid;methyl (2S)-2-benzamido-5-(diaminomethylideneamino)pentanoate
Synonyms
Bz-L-Arg-OMe Carbonate; BENZOYL-ARG-OH; N-BENZOYL-L-ARGININE; BZ-ARG-OH; BZO-ARG-OH; Bz-L-Arg-OH
Appearance
White powder
Purity
≥ 97% (TLC)
Melting Point
145-147 °C
Boiling Point
662.0 °C at 760 mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C14H20N4O3.CH2O3/c1-21-13(20)11(8-5-9-17-14(15)16)18-12(19)10-6-3-2-4-7-10;2-1(3)4/h2-4,6-7,11H,5,8-9H2,1H3,(H,18,19)(H4,15,16,17);(H2,2,3,4)/t11-;/m0./s1
InChI Key
JYDGTEAWFBDILR-MERQFXBCSA-N
Canonical SMILES
COC(=O)C(CCCN=C(N)N)NC(=O)C1=CC=CC=C1.C(=O)(O)O

Nα-Benzoyl-L-arginine methyl ester carbonate, a versatile chemical compound widely employed in biochemical research and various bioscience applications, showcases notably high perplexity and burstiness in its key applications:

Protease Activity Assays: Acting as a substrate in assays targeting serine proteases like trypsin, Nα-Benzoyl-L-arginine methyl ester carbonate undergoes hydrolysis to yield measurable products, offering crucial insights into enzyme kinetics and functionality. This utilization plays a pivotal role in unraveling enzyme mechanisms and facilitating inhibitor screening, shedding light on the intricate world of enzyme activities.

Pharmaceutical Research: Embedded in the realms of drug development, Nα-Benzoyl-L-arginine methyl ester carbonate aids in identifying potent inhibitors for serine proteases, crucial targets for conditions like clotting disorders and inflammatory diseases. Through drug screens incorporating this compound, researchers scout for novel therapeutics with precise enzyme modulatory effects, steering the course of pharmaceutical innovation towards tailored treatments.

Protein Engineering: Driving protein engineering endeavors, Nα-Benzoyl-L-arginine methyl ester carbonate serves as a key player in dissecting the structure-function relationships of proteases. By monitoring how mutations impact substrate hydrolysis, scientists glean insights into the architecture of active sites and the dynamics of enzymes, propelling the design of proteases with customized specificities.

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