N-Boc-cis-4-hydroxy-L-proline
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N-Boc-cis-4-hydroxy-L-proline

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N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Category
BOC-Amino Acids
Catalog number
BAT-003092
CAS number
87691-27-8
Molecular Formula
C10H17NO5
Molecular Weight
231.25
N-Boc-cis-4-hydroxy-L-proline
IUPAC Name
(2S,4S)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Synonyms
Boc-cis-Hyp-OH; (2S,4S)-1-(t-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid; (2S,4S)-cis-1-N-Boc-4-hydroxy-proline; Boc-(2S,4S)-(-)-4-hydroxypyrrolidine-2-carboxylic acid; Boc-cis-4-hydroxy-L-proline
Appearance
White to off white powder
Purity
≥ 98% (TLC)
Density
1.312±0.060 g/cm3
Melting Point
142-147 °C
Boiling Point
390.9±42.0 °C
Storage
Store at 2-8 °C
InChI
InChI=1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m0/s1
InChI Key
BENKAPCDIOILGV-BQBZGAKWSA-N
Canonical SMILES
CC(C)(C)OC(=O)N1CC(CC1C(=O)O)O
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