N-Fmoc-α-methyl-4-tert-butoxy-L-phenylalanine
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N-Fmoc-α-methyl-4-tert-butoxy-L-phenylalanine

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N-Fmoc-α-methyl-4-tert-butoxy-L-phenylalanine is pivotal in peptide synthesis, offering precise control over the modification and assembly of peptide chains. The Fmoc protecting group ensures the selective reactivity of the amino group, while the α-methyl and tert-butoxy modifications provide unique structural and functional properties that are valuable in the development of peptides and peptidomimetics for pharmaceutical applications.

Category
Fmoc-Amino Acids
Catalog number
BAT-016486
CAS number
1309873-74-2
Molecular Formula
C29H31NO5
Molecular Weight
473.56
N-Fmoc-α-methyl-4-tert-butoxy-L-phenylalanine
IUPAC Name
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-methyl-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid
Synonyms
O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-methyl-L-tyrosine; Fmoc-aMeTyr(tBu)-OH; N-(fluorenylmethoxycarbonyl)-alpha-methyl-O4-tert-butyl-L-tyrosine; Fmoc-α-Me-Tyr(tBu)-OH; (S)-2-Fmoc-amino-3-(4-(tert-butoxy)phenyl)-2-methylpropanoic acid
Purity
≥95%
Density
1.204±0.06 g/cm3
Boiling Point
661.1±55.0 °C at 760 mmHg
InChI
InChI=1S/C29H31NO5/c1-28(2,3)35-20-15-13-19(14-16-20)17-29(4,26(31)32)30-27(33)34-18-25-23-11-7-5-9-21(23)22-10-6-8-12-24(22)25/h5-16,25H,17-18H2,1-4H3,(H,30,33)(H,31,32)/t29-/m0/s1
InChI Key
GYJQWNBTHBMFNN-LJAQVGFWSA-N
Canonical SMILES
CC(C)(C)OC1=CC=C(C=C1)CC(C)(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
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