Nα-Fmoc-Nα-methyl-Nω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine
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Nα-Fmoc-Nα-methyl-Nω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine

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Category
Fmoc-Amino Acids
Catalog number
BAT-003673
CAS number
214750-72-8
Molecular Formula
C32H38N4O7S
Molecular Weight
622.90
Nα-Fmoc-Nα-methyl-Nω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine
IUPAC Name
(2S)-5-[[amino-[(4-methoxy-2,3,6-trimethylphenyl)sulfonylamino]methylidene]amino]-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]pentanoic acid
Synonyms
Fmoc-N-Me-L-Arg(Mtr)-OH; (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-5-(3-((4-Methoxy-2,3,6-Trimethylphenyl)Sulfonyl)Guanidino)Pentanoic Acid
Appearance
White to off-white powder
Purity
≥ 98% (HPLC)
Density
1.32 g/cm3
Boiling Point
798.5±70.0 °C(Predicted)
Storage
Store at-20 °C
InChI
InChI=1S/C32H38N4O7S/c1-19-17-28(42-5)20(2)21(3)29(19)44(40,41)35-31(33)34-16-10-15-27(30(37)38)36(4)32(39)43-18-26-24-13-8-6-11-22(24)23-12-7-9-14-25(23)26/h6-9,11-14,17,26-27H,10,15-16,18H2,1-5H3,(H,37,38)(H3,33,34,35)/t27-/m0/s1
InChI Key
LNVHMIGZISCVKC-MHZLTWQESA-N
Canonical SMILES
CC1=CC(=C(C(=C1S(=O)(=O)NC(=NCCCC(C(=O)O)N(C)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)N)C)C)OC

Nα-Fmoc-Nα-methyl-Nω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine, a synthetic amino acid derivative, finds diverse applications in bioscience. Here are the key applications presented with high perplexity and burstiness.

Peptide Synthesis: Integral to solid-phase peptide synthesis, this compound serves as a protected amino acid, facilitating the assembly of intricate peptides by temporarily shielding functional groups to prevent unwanted reactions. This process enables the precise and efficient synthesis of peptides with exceptional purity and yield, pushing the boundaries of peptide chemistry.

Drug Design and Development: Positioned at the forefront of drug innovation, Nα-Fmoc-Nα-methyl-Nω-(4-methoxy-236-trimethylbenzenesulfonyl)-L-arginine plays a pivotal role in designing novel therapeutic peptides and peptidomimetics. Leveraging its unique chemical properties, researchers can enhance the stability, bioavailability, and specificity of drug candidates.

Proteomics Research: In the realm of proteomics, this compound is a vital tool for modifying and labeling proteins. By reacting selectively with specific amino acid residues, it contributes to the exploration of protein structure, function, and interactions, unlocking crucial insights into biomarkers, disease pathways, and diagnostic tool development. The utilization of this derivative is paramount for advancing our understanding of the intricate world of proteins.

Bioconjugation: A key player in bioconjugation methodologies, this derivative is employed to link peptides or proteins to diverse biomolecules or surfaces such as antibodies, enzymes, or other proteins, amplifying their detection sensitivity, activity, or stability. These modifications hold significant implications for diagnostics, therapeutics, and biosensor applications, underscoring the versatile utility of this compound in the bioscience landscape.

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