Nα-Fmoc-Nδ-xanthyl-D-glutamine
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Nα-Fmoc-Nδ-xanthyl-D-glutamine

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category
Fmoc-Amino Acids
Catalog number
BAT-001976
CAS number
1313054-52-2
Molecular Formula
C33H28N2O6
Molecular Weight
548.60
IUPAC Name
(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-(9H-xanthen-9-ylamino)pentanoic acid
Synonyms
Fmoc-D-Gln(Xan)-OH
Appearance
White powder
Purity
≥ 99% (HPLC)
Melting Point
192-198°C
Storage
Store at 2-8 °C
InChI
InChI=1S/C33H28N2O6/c36-30(35-31-24-13-5-7-15-28(24)41-29-16-8-6-14-25(29)31)18-17-27(32(37)38)34-33(39)40-19-26-22-11-3-1-9-20(22)21-10-2-4-12-23(21)26/h1-16,26-27,31H,17-19H2,(H,34,39)(H,35,36)(H,37,38)/t27-/m1/s1
InChI Key
DQGRFJKGDGJKFV-HHHXNRCGSA-N
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CCC(=O)NC4C5=CC=CC=C5OC6=CC=CC=C46)C(=O)O

Nα-Fmoc-Nδ-xanthyl-D-glutamine is a specialized amino acid derivative used in the field of peptide synthesis and bioconjugation. Here are some key applications of Nα-Fmoc-Nδ-xanthyl-D-glutamine:

Peptide Synthesis: Nα-Fmoc-Nδ-xanthyl-D-glutamine is utilized in solid-phase peptide synthesis as a protecting group for the glutamine side chain. Its use ensures the selective modification of peptides, preventing unwanted side reactions during synthesis. This contributes to the production of high-purity peptides for research and therapeutic applications.

Bioconjugation: This compound can be employed in bioconjugation techniques to attach bioactive molecules to peptides or proteins. By using Nα-Fmoc-Nδ-xanthyl-D-glutamine, researchers can introduce functional groups that facilitate the conjugation of therapeutic agents, imaging probes, or other biomolecules. This approach is key for developing targeted drug delivery systems and innovative diagnostics.

Structural Biology: Nα-Fmoc-Nδ-xanthyl-D-glutamine finds application in structural biology for studying protein-ligand interactions. It allows the incorporation of specific labels or probes into peptides, aiding in the investigation of protein-binding sites and conformational changes. This information is crucial for drug design and understanding protein function on a molecular level.

Chemical Biology: In chemical biology, Nα-Fmoc-Nδ-xanthyl-D-glutamine can be used to study post-translational modifications in proteins. By incorporating this derivative into proteins, researchers can mimic natural modifications and assess their effects on protein activity and stability. This assists in unraveling complex biological processes and developing targeted therapeutic strategies.

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