Nα-Fmoc-Nδ-xanthyl-L-glutamine
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Nα-Fmoc-Nδ-xanthyl-L-glutamine

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Category
Fmoc-Amino Acids
Catalog number
BAT-003696
CAS number
185031-81-6
Molecular Formula
C33H28N2O6
Molecular Weight
548.57
Nα-Fmoc-Nδ-xanthyl-L-glutamine
IUPAC Name
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-(9H-xanthen-9-ylamino)pentanoic acid
Synonyms
Fmoc-L-Gln(Xan)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((9H-xanthen-9-yl)amino)-5-oxopentanoic acid; n-alfa-fmoc-n-xanthyl-l-glutamine
Appearance
White powder
Purity
≥ 99% (HPLC)
Melting Point
191-197 °C
Storage
Store at 2-8°C
InChI
InChI=1S/C33H28N2O6/c36-30(35-31-24-13-5-7-15-28(24)41-29-16-8-6-14-25(29)31)18-17-27(32(37)38)34-33(39)40-19-26-22-11-3-1-9-20(22)21-10-2-4-12-23(21)26/h1-16,26-27,31H,17-19H2,(H,34,39)(H,35,36)(H,37,38)/t27-/m0/s1
InChI Key
DQGRFJKGDGJKFV-MHZLTWQESA-N
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CCC(=O)NC4C5=CC=CC=C5OC6=CC=CC=C46)C(=O)O

Nα-Fmoc-Nδ-xanthyl-L-glutamine, a derivative of the amino acid glutamine, plays a pivotal role in peptide synthesis within the realm of bioscience. Here are four key applications of Nα-Fmoc-Nδ-xanthyl-L-glutamine:

Peptide Synthesis: Embedded in solid-phase peptide synthesis (SPPS), Nα-Fmoc-Nδ-xanthyl-L-glutamine acts as a shielded iteration of glutamine. The presence of the Fmoc group enables targeted deprotection during the assembling of peptide chains, ensuring precise synthesis. This compound is indispensable for crafting bespoke peptides with intricate sequences, tailored for both research endeavors and therapeutic interventions.

Drug Design: Within the domain of pharmaceutical exploration, Nα-Fmoc-Nδ-xanthyl-L-glutamine emerges as a fundamental component in the construction of peptide-driven drugs. Its durability and responsiveness foster the creation of compounds endowed with heightened pharmacological attributes. By integrating this derivative, scientists can refine peptide drugs to enhance bioavailability and specificity in targeting, forging a path towards more effective pharmaceutical solutions.

Bioconjugation: Nα-Fmoc-Nδ-xanthyl-L-glutamine finds application in bioconjugation methodologies aimed at tethering peptides to diverse biomolecules or surfaces. This utilization holds significance in the development of diagnostic instruments and precision-targeted drug delivery mechanisms. Employing this derivative facilitates the formulation of stable and functional conjugates for a myriad of biotechnological purposes, showcasing its versatility in innovative scientific pursuits.

Protein Engineering: Enlisted in the realm of protein engineering, Nα-Fmoc-Nδ-xanthyl-L-glutamine is harnessed to introduce specific alterations into proteins or enzymes. Through the incorporation of modified glutamine residues, researchers can explore protein functionality and endurance. This strategy aids in deciphering protein interactions and crafting proteins imbued with superior therapeutic or industrial attributes.

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