N-Me-L-norleucine hydrochloride
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N-Me-L-norleucine hydrochloride

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Category
L-Amino Acids
Catalog number
BAT-005629
CAS number
17343-27-0
Molecular Formula
C7H15NO2
Molecular Weight
145.2
N-Me-L-norleucine hydrochloride
IUPAC Name
(2S)-2-(methylamino)hexanoic acid
Synonyms
N-Me-L-Nle-OH HCl; N-Me-L-2-aminohexanoic acid
Appearance
White solid
Purity
≥ 98% (HPLC)
Storage
Store at 2-8°C
InChI
InChI=1S/C7H15NO2/c1-3-4-5-6(8-2)7(9)10/h6,8H,3-5H2,1-2H3,(H,9,10)/t6-/m0/s1
InChI Key
FPDYKABXINADKS-LURJTMIESA-N
Canonical SMILES
CCCCC(C(=O)O)NC
1. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
2. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
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