N-α-Methyl-D-alanine
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N-α-Methyl-D-alanine

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Category
D-Amino Acids
Catalog number
BAT-004770
CAS number
29475-64-7
Molecular Formula
C4H9NO2
Molecular Weight
103.12
N-α-Methyl-D-alanine
IUPAC Name
(2R)-2-(methylamino)propanoic acid
Synonyms
H-D-MeAla-OH; (R)-2-(Methylamino)propanoic acid
Appearance
White to off-white powder
Purity
≥ 98% (HPLC)
Density
1.048±0.06 g/cm3(Predicted)
Boiling Point
190.1±23.0 °C(Predicted)
Storage
Store at 2-8°C
InChI
InChI=1S/C4H9NO2/c1-3(5-2)4(6)7/h3,5H,1-2H3,(H,6,7)/t3-/m1/s1
InChI Key
GDFAOVXKHJXLEI-GSVOUGTGSA-N
Canonical SMILES
CC(C(=O)O)NC

N-α-Methyl-D-alanine (MeD-Ala) boasts a versatile nature as a non-proteinogenic amino acid, finding applications in both biochemical studies and industrial processes. Here are the key applications of N-α-Methyl-D-alanine presented with a high degree of perplexity and burstiness:

Pharmaceutical Development: Leading the charge in peptide-based drug innovation, N-α-Methyl-D-alanine plays a pivotal role in enhancing the stability and bioavailability of therapeutic peptides. By integrating MeD-Ala into these peptides, researchers fortify them against enzymatic breakdown and extend their lifespan in the bloodstream. This strategic modification sets the stage for more potent treatments across a spectrum of conditions, from metabolic disorders to bacterial infections.

Biochemical Research: Delving into the realm of biochemical research, N-α-Methyl-D-alanine emerges as a powerful tool for unraveling enzyme mechanisms and protein interactions. Its unique molecular structure enables it to function as both a substrate and inhibitor in enzymatic assays, shedding light on enzyme specificity and activity. This application not only aids in decoding fundamental biochemical pathways but also aids in pinpointing potential drug targets, laying the groundwork for groundbreaking discoveries.

Peptide Synthesis: A cornerstone in peptide synthesis, N-α-Methyl-D-alanine is a go-to resource for crafting custom peptides, particularly in the realm of designing analogs with enhanced properties. By substituting natural amino acids with MeD-Ala, researchers engineer peptides with heightened binding affinity and modified biological activities. This cutting-edge approach proves invaluable in the development of peptide-based diagnostics and therapeutics, pushing the boundaries of medical innovation.

Industrial Biotechnology: In the dynamic landscape of industrial biotechnology, N-α-Methyl-D-alanine finds its niche in the engineering of microorganisms for the synthesis of specialty chemicals and biopolymers. By integrating MeD-Ala into microbial metabolic pathways, scientists unlock the potential to produce novel compounds with desirable characteristics. This innovative approach opens avenues for the creation of new materials with applications spanning healthcare, agriculture, and environmental sustainability, heralding a new era of biotechnological advancements.

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